Asset Details
Do you wish to reserve the book?
Non-serous ovarian cancer in PTEN Hamartoma Tumor Syndrome: additional evidence for increased risk
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Non-serous ovarian cancer in PTEN Hamartoma Tumor Syndrome: additional evidence for increased risk
Do you wish to request the book?
Non-serous ovarian cancer in PTEN Hamartoma Tumor Syndrome: additional evidence for increased risk
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Non-serous ovarian cancer in PTEN Hamartoma Tumor Syndrome: additional evidence for increased risk
2025
Overview
Increased hereditary cancer risk is one of the hallmarks of PTEN Hamartoma Tumor Syndrome (PHTS) which is caused by a pathogenic germline variant in PTEN . Case reports and some cohort studies have described ovarian cancer (OC) in PHTS patients. Previously, we observed an enrichment of non-serous OC in PHTS compared to sporadic cases (3% vs 1%). However, ovarian cancer is currently not considered a PHTS-related cancer. The aim of this study was to describe five PHTS patients with a pathogenic germline variant in PTEN with non-serous OC. Three of the non-serous OCs were mucinous carcinomas (49, 51 and 52 years) and two were malignant germ cell tumors (8 and 15 years) and all were diagnosed before genetic testing and PHTS diagnosis. In addition to OC, the described patients developed other PHTS-related benign and malignant lesions. We provide further evidence that non-serous ovarian cancer, especially mucinous, endometrioid and malignant germ cell tumors should be further investigated as potential PHTS-related cancers.
Publisher
Springer Nature B.V,Springer Netherlands
Subject
Adenocarcinoma, Mucinous - genetics
/ Adenocarcinoma, Mucinous - pathology
/ Adult
/ Female
/ Genetic Predisposition to Disease
/ Hamartoma Syndrome, Multiple - complications
/ Hamartoma Syndrome, Multiple - genetics
/ Humans
/ Neoplasms, Germ Cell and Embryonal - genetics
/ Neoplasms, Germ Cell and Embryonal - pathology
/ Ovarian Neoplasms - genetics
/ Ovarian Neoplasms - pathology
/ PTEN Phosphohydrolase - genetics
/ Tumors
