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Real‐world evidence for preventive effects of statins on cancer incidence: A trans‐Atlantic analysis

by Zincke, Fabian , Eckert, Andreas , Lewis, Joe , Walther, Wolfgang , Kobelt, Dennis , Liebeskind, Juliane Maria , Gohlke, Bjoern‐O , Preissner, Robert , Stein, Ulrike , Preissner, Sally , Putzker, Kerstin , Mura, Cameron , Bourne, Philip E. , Gunkel, Nikolas , Kortüm, Benedikt , Preissner, Saskia

in Biomarkers / cancer / Cancer therapies / Colorectal cancer / Drug dosages / electronic health record / Electronic health records / Gastric cancer / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology / Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use / Incidence / Letter to Editor / Liver cancer / MACC1 / Metastasis / Mortality / Neoplasms - drug therapy / Neoplasms - prevention & control / Protective Factors / real‐world evidence / statin / Statins

2022

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Real‐world evidence for preventive effects of statins on cancer incidence: A trans‐Atlantic analysis

2022

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Real‐world evidence for preventive effects of statins on cancer incidence: A trans‐Atlantic analysis

2022

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Journal Article

Real‐world evidence for preventive effects of statins on cancer incidence: A trans‐Atlantic analysis

Zincke, Fabian,

Eckert, Andreas,

Lewis, Joe,

Walther, Wolfgang,

Kobelt, Dennis,

Liebeskind, Juliane Maria,

Gohlke, Bjoern‐O,

Preissner, Robert,

Stein, Ulrike,

Preissner, Sally,

Putzker, Kerstin,

Mura, Cameron,

Bourne, Philip E.,

Gunkel, Nikolas,

Kortüm, Benedikt,

Preissner, Saskia

2022

Overview

In vivo, we treated CRC xenografted SCID-beige mice with a human equivalent statin dose, which reduced MACC1 expression, tumour burden and metastasis formation (day 24; control vs. statin treatment p < .0001, Figure S2 and Figure 2). [...]at a molecular/mechanistic level, we provide experimental evidence that statins act, at least partly, by inhibiting transcription of the tumour-promoting and metastasis-inducing MACC1 gene. [...]we extended the RWE results by utilizing a clinical research platform (TriNetX) to access a large, international cohort of anonymized electronic health record (EHR) data (aggregate statistics only). [...]our study revealed strong evidence for cancer-preventive effects of statins in a large trans-Atlantic cohort, comprised of long-term statin users.

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Publisher

John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley

Subject

/ cancer

/ electronic health record

/ Electronic health records