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The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial
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The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial
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Journal Article
The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial
2021
Overview
Platelet-rich plasma (PRP) showed positive results in the improvement of skin aging. Lyophilized PRP can be interesting in clinical practice due to the facility to obtain many samples in a single blood collection and can be used in multiple injections. To evaluate the effect of lyophilized PRP in the treatment of skin aging, through a Phase II pilot study. Nineteen women (54 years ± 7 years) with Glogau photoaging II and III types were select for this non-randomized, split-face controlled study. They received monthly intradermal injections of lyophilized PRP and saline solution (as control) into the facial skin, during a period of 2 months. The evaluation was performed by imaging method, histological techniques, and multiphoton microscopy. Although lyophilized PRP presented 10 times the platelet baseline value (
P
< .0001) and growth factors in adequate levels, only saline solution showed an increase of dermis thickness (
p
= .0009). Collagen pre and post-application remained the same for both types of treatments. The use of lyophilized PRP by mesotherapy showed no improvement on skin aging.
Trial registration approval
RBR-3n9wxw, UTN U1111-1226-6093-retrospectively registered.
