Asset Details
Do you wish to reserve the book?
Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
Do you wish to request the book?
Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
2019
Overview
Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression. T1D is considered as a multifactorial disease, in which genetic predisposition and environmental factors interact to promote the triggering of autoimmune responses against beta cells. Over the last decades, it has become clear that vitamin D exerts anti-inflammatory and immunomodulatory effects, apart from its well-established role in the regulation of calcium homeostasis and bone metabolism. Importantly, the global incidence of vitamin D deficiency is also dramatically increasing and epidemiologic evidence suggests an involvement of vitamin D deficiency in T1D pathogenesis. Polymorphisms in genes critical for vitamin D metabolism have also been shown to modulate the risk of T1D. Moreover, several studies have investigated the role of vitamin D (in different doses and formulations) as a potential adjuvant immunomodulatory therapy in patients with new-onset and established T1D. This review aims to present the current knowledge on the immunomodulatory effects of vitamin D and summarize the clinical interventional studies investigating its use for prevention or treatment of T1D.
Publisher
MDPI AG,MDPI
Subject
/ Adult
/ Animals
/ Antigens
/ calcium
/ Child
/ Diabetes
/ Diabetes Mellitus, Type 1 - drug therapy
/ Diabetes Mellitus, Type 1 - epidemiology
/ Diabetes Mellitus, Type 1 - immunology
/ Diabetes Mellitus, Type 1 - metabolism
/ Female
/ genes
/ genetic predisposition to disease
/ Humans
/ Immunologic Factors - therapeutic use
/ Insulin
/ insulin-dependent diabetes mellitus
/ Insulin-Secreting Cells - drug effects
/ Insulin-Secreting Cells - immunology
/ Insulin-Secreting Cells - metabolism
/ Male
/ Medicine
/ patients
/ Review
/ risk
/ Vitamin D Deficiency - drug therapy
/ Vitamin D Deficiency - epidemiology
/ Vitamin D Deficiency - immunology
