Journal Article

Dietary Factors Associated with Plasma Thyroid Peroxidase and Thyroglobulin Antibodies

Matana, Antonela, Punda, Ante, Lozić, Bernarda, Polašek, Ozren, Torlak, Vesela, Brdar, Dubravka, Perica, Vesna Boraska, Popović, Marijana, Barbalić, Maja, Zemunik, Tatijana, Hayward, Caroline

2017

Overview

The knowledge about dietary habits and their influence in the development of autoimmune thyroid disease is insufficient. The aim of this study was to analyse the association of dietary factors and plasma thyroid peroxidase antibodies (TPO-Ab) and/or thyroglobulin antibodies (Tg-Ab). The study enrolled 1887 participants originating from the South Croatia. Participants with elevated plasma TPO-Ab and/or Tg-Ab were defined as cases (n = 462) and those with TPO-Ab and/or Tg-Ab within referent values were defined as controls (n = 1425). Dietary intake was evaluated according to a food frequency questionnaire containing 58 food items. Principal component analysis was used to group food items into dietary groups. We used logistic regression analysis to examine dietary groups associated with positive plasma TPO-Ab and/or Tg-Ab. The results indicate that the dietary group with frequent consumption of animal fats and butter is associated with positive plasma TPO-Ab and/or Tg-Ab (p = 0.01). The dietary group with frequent consumption of vegetables as well as the dietary group with high consumption of dried fruit, nuts, and muesli are associated with negative findings of TPO-Ab and/or Tg-Ab (p = 0.048 and p = 0.02, respectively). We showed that the anti-inflammatory dietary groups are associated with the negative findings of plasma TPO-Ab and/or Tg-Ab.

• Publisher: MDPI AG,MDPI
• Subject: Adult / Aged / animal fats and oils / Antibodies / Autoantibodies - blood / Autoantigens - immunology / Autoimmune Diseases - blood / Autoimmune Diseases - immunology / Autoimmune Diseases - prevention & control / Biomarkers - blood / butter / Case-Control Studies / Chi-Square Distribution / Croatia / Cross-Sectional Studies / Diet - adverse effects / dried fruit / eating habits / Feeding Behavior / Female / food frequency questionnaires / food intake / Humans / Immunoglobulins / iodide peroxidase / Iodide Peroxidase - immunology / Iron-Binding Proteins - immunology / Logistic Models / Male / Metabolic disorders / Middle Aged / nuts / Odds Ratio / Plasma / Principal Component Analysis / Principal components analysis / Protective Factors / regression analysis / Risk Factors / thyroglobulin / Thyroglobulin - immunology / thyroid diseases / Thyroid Diseases - blood / Thyroid Diseases - immunology / Thyroid Diseases - prevention & control / Thyroid gland / Up-Regulation / vegetables