Asset Details
Do you wish to reserve the book?
A comprehensive review of lysine-specific demethylase 1 and its roles in cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A comprehensive review of lysine-specific demethylase 1 and its roles in cancer
Do you wish to request the book?
A comprehensive review of lysine-specific demethylase 1 and its roles in cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A comprehensive review of lysine-specific demethylase 1 and its roles in cancer
2017
Overview
Histone methylation plays a key role in the regulation of chromatin structure, and its dynamics regulates important cellular processes. The investigation of the role of alterations in histone methylation in cancer has led to the identification of histone methyltransferases and demethylases as promising novel targets for therapy. Lysine-specific demethylase 1(LSD1, also known as KDM1A) is the first discovered histone lysine demethylase, with the ability to demethylase H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. LSD1 regulates the balance between self-renewal and differentiation of stem cells, and is highly expressed in various cancers, playing an important role in differentiation and self-renewal of tumor cells. In this review, we summarize recent studies about the LSD1, its role in normal and tumor cells, and the potential use of small molecule LSD1 inhibitors in therapy.
Publisher
Future Medicine Ltd
Subject
/ Antineoplastic Agents - pharmacology
/ Antineoplastic Agents - therapeutic use
/ cancer
/ Enzyme Inhibitors - pharmacology
/ Enzyme Inhibitors - therapeutic use
/ Enzymes
/ Gene Expression Regulation, Neoplastic
/ Histone Demethylases - antagonists & inhibitors
/ Histone Demethylases - genetics
/ Histone Demethylases - metabolism
/ Histones
/ Humans
/ KDM1A
/ Leukemia
/ LSD1
/ Lysine
/ MC2580
/ NCD38
/ OG86
/ ORY-1001
/ Proteins
/ SP2509
/ Therapy
/ Tumors
