Asset Details
Do you wish to reserve the book?
Changes in highly sensitive alpha‐fetoprotein for the prediction of the outcome in patients with hepatocellular carcinoma after hepatectomy
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Changes in highly sensitive alpha‐fetoprotein for the prediction of the outcome in patients with hepatocellular carcinoma after hepatectomy
Do you wish to request the book?
Changes in highly sensitive alpha‐fetoprotein for the prediction of the outcome in patients with hepatocellular carcinoma after hepatectomy
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Changes in highly sensitive alpha‐fetoprotein for the prediction of the outcome in patients with hepatocellular carcinoma after hepatectomy
2014
Overview
We investigated changes in highly sensitive lens culinaris agglutinin A‐reactive fraction of alpha‐fetoprotein (hsAFP‐L3) measured using a novel method and its predictive ability for prognosis in patients with hepatocellular carcinoma (HCC) who underwent curative hepatectomy, comparing to other HCC tumor markers, that is, AFP, des‐gamma‐carboxy prothrombin (DCP), and AFP‐L3 measured with conventional method (cAFP‐L3). AFP, DCP, and AFP‐L3 including both cAFP‐L3 and hsAFP‐L3 were measured before and after curative hepatectomy in 187 patients. The percentage of patients with elevated tumor marker levels pre‐ and postoperatively was compared, and recurrence‐free and overall survival rates were analyzed based on changes in tumor markers. The percentages of patients with elevated AFP, DCP, and cAFP‐L3 decreased postoperatively. In contrast, the percentage of patients with elevated hsAFP‐L3 did not decrease postoperatively. Both recurrence‐free and overall survival rates were significantly lower in patients whose tumor marker levels remained elevated postoperatively than patients without tumor marker elevation postoperatively. Recurrence‐free and overall survival rates of patients in whom hsAFP‐L3 became elevated postoperatively despite normal preoperative hsAFP‐L3 levels were significantly lower than those of patients with normal hsAFP‐L3 postoperatively, and were similar to those of patients with persistent elevation. Preoperative elevations of AFP, DCP, and cAFP normalized in many patients postoperatively, but not for hsAFP‐L3. The elevation of hsAFP‐L3 identifies patients with poor prognosis despite the normalization of AFP and DCP. AFP‐L3, tumor biomarker that is specific for hepatocellular carcinoma (HCC) usually decreases after curative hepatectomy as well as AFP and des‐gamma‐carboxy prothrombin. However, it did not decrease even after curative hepatectomy when AFP‐L3 was measured with highly sensitive method, and this will discriminate the outcome of patients with HCC after hepatectomy.
Publisher
John Wiley & Sons, Inc,BlackWell Publishing Ltd
Subject
/ Aged
/ alpha-Fetoproteins - biosynthesis
/ alpha-Fetoproteins - genetics
/ Carcinoma, Hepatocellular - genetics
/ Carcinoma, Hepatocellular - pathology
/ Carcinoma, Hepatocellular - surgery
/ Changes
/ Enzymes
/ Female
/ highly sensitive measurement of AFP‐L3
/ Humans
/ Male
/ Neoplasm Recurrence, Local - genetics
/ Neoplasm Recurrence, Local - pathology
/ Neoplasm Recurrence, Local - surgery
/ NMR
/ Patients
