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Normative data for insulin-like growth factor-1 and insulin-like growth factor binding protein-3 and their determinants in healthy adult males from india: the INDIIGo study
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Normative data for insulin-like growth factor-1 and insulin-like growth factor binding protein-3 and their determinants in healthy adult males from india: the INDIIGo study
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Journal Article
Normative data for insulin-like growth factor-1 and insulin-like growth factor binding protein-3 and their determinants in healthy adult males from india: the INDIIGo study
2025
Overview
The INDIIGo study aimed to establish normative data for serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) in adult Indian males, addressing the paucity of data for the South East Asian population. This cross-sectional study included 1271 healthy males aged 20 to 65.9 years from Chandigarh, India, with measurements obtained using the Roche Elecsys electrochemiluminescence immunoassay (ECLIA). Age-specific normative centile curves were generated using the LMS (Lambda, Mu, Sigma) method. Serum IGF-1 levels declined by 30.1 ng/ml per decade (95% CI − 34.9 to − 25.2;
p
< 0.001) and were negatively associated with lower socioeconomic status (− 5.8 ng/ml per class;
p
= 0.002), ALT (− 0.6 ng/ml per unit;
p
< 0.001), and HbA1c (− 8.2 ng/ml per category;
p
= 0.04). Positive correlations were observed with serum T4 (+ 4.5 ng/ml per unit;
p
< 0.001) and serum albumin (+ 18.0 ng/ml per g/dL;
p
= 0.009). IGFBP-3 levels decreased by 447.8 ng/ml per decade (95% CI − 547.6 to − 348.1;
p
< 0.001), with a significant positive association with serum T4 (+ 60.8 ng/ml per unit;
p
= 0.025). This study provides age-specific normative data for IGF-1 and IGFBP-3 in Indian males and identifies key factors influencing these biomarkers.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/53
/ Adult
/ Adults
/ Age
/ Aged
/ ECLIA
/ Humanities and Social Sciences
/ Humans
/ IGF-1
/ IGFBP-3
/ India
/ Insulin
/ Insulin-Like Growth Factor Binding Protein 3 - blood
/ Insulin-like growth factor I
/ Insulin-Like Growth Factor I - analysis
/ Insulin-Like Growth Factor I - metabolism
/ Insulin-like growth factor-binding protein 3
/ Male
/ Males
/ Obesity
/ Roche
/ Science
