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The Rcs regulon in Proteus mirabilis: implications for motility, biofilm formation, and virulence
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The Rcs regulon in Proteus mirabilis: implications for motility, biofilm formation, and virulence
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Journal Article
The Rcs regulon in Proteus mirabilis: implications for motility, biofilm formation, and virulence
2016
Overview
The overall role of the Rcs phosphorelay in
Proteus mirabilis
is largely unknown. Previous work had demonstrated that the Rcs phosphorelay represses the
flhDC
operon and activates the
minCDE
cell division inhibition system. To identify additional cellular functions regulated by the Rcs phosphorelay, an analysis of RNA-seq data was undertaken. In this report, the results of the RNA-sequencing are discussed with an emphasis on the predicted roles of the Rcs phosphorelay in swarmer cell differentiation, motility, biofilm formation, and virulence. RcsB is shown to activate genes important for differentiation and fimbriae formation, while repressing the expression of genes important for motility and virulence. Additionally, to follow up on the RNA-Seq data, we demonstrate that an
rcsB
mutant is deficient in its ability to form biofilm and exhibits enhanced virulence in a
Galleria mellonella
waxworm model. Overall, these results indicate the Rcs regulon in
P. mirabilis
extends beyond flagellar genes to include those involved in biofilm formation and virulence. Furthermore, the information presented in this study may provide clues to additional roles of the Rcs phosphorelay in other members of the
Enterobacteriaceae
.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ biofilm
/ Biofilms
/ Biomedical and Life Sciences
/ E coli
/ fimbriae
/ Flagella
/ Gene Expression Regulation, Bacterial
/ Genes
/ Kinases
/ Microbial Genetics and Genomics
/ Motility
/ mutants
/ Mutation
/ Operon
/ Pili
/ Proteins
/ Proteus mirabilis - pathogenicity
/ Proteus mirabilis - physiology
/ regulon
/ RNA
