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Technique, safety, and feasibility of EUS-guided radiofrequency ablation in unresectable pancreatic cancer
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Technique, safety, and feasibility of EUS-guided radiofrequency ablation in unresectable pancreatic cancer
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Technique, safety, and feasibility of EUS-guided radiofrequency ablation in unresectable pancreatic cancer
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Journal Article
Technique, safety, and feasibility of EUS-guided radiofrequency ablation in unresectable pancreatic cancer
2018
Overview
Background and aimsRadiofrequency ablation (RFA) is a well-recognized local ablative technique applied in the treatment of different solid tumors. Intraoperative RFA has been used for non-metastatic unresectable pancreatic ductal adenocarcinoma (PDAC), showing increased overall survival in retrospective studies. A novel RFA probe has recently been developed, allowing RFA under endoscopic ultrasound (EUS) guidance. Aim of the present study was to assess the feasibility and safety of EUS-guided RFA for unresectable PDACs.MethodsPatients with unresectable non-metastatic PDAC were included in the study following neoadjuvant chemotherapy. EUS-guided RFA was performed using a novel monopolar 18-gauge electrode with a sharp conical 1 cm tip for energy delivery. Pre- and post-procedural clinical and radiological data were prospectively collected.ResultsTen consecutive patients with unresectable PDAC were enrolled. The procedure was successful in all cases and no major adverse events were observed. A delineated hypodense ablated area within the tumor was observed at the 30-day CT scan in all cases.ConclusionsEUS-guided RFA is a feasible and safe minimally invasive procedure for patients with unresectable PDAC. Further studies are warranted to demonstrate the impact of EUS-guided RFA on disease progression and overall survival.
Publisher
Springer Nature B.V
Subject
