Asset Details
Do you wish to reserve the book?
An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure
Do you wish to request the book?
An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure
2020
Overview
Patients with kidney failure commonly require dialysis to remove nitrogenous wastes and to reduce burden to the kidney. Here, we show that a bacterial cocktail orally delivered in animals with kidney injury can metabolize blood nitrogenous waste products before they diffuse through the intestinal mucosal barrier. The microbial cocktail consists of three strains of bacteria isolated from faecal microbiota that metabolize urea and creatinine into amino acids, and is encapsulated in calcium alginate microspheres coated with a polydopamine layer that is selectively permeable to small-molecule nitrogenous wastes. In murine models of acute kidney injury and chronic kidney failure, and in porcine kidney failure models, the encapsulated microbial cocktail significantly reduced urea and creatinine concentrations in blood, and did not lead to any adverse effects.
An orally delivered encapsulated bacterial cocktail that metabolizes blood nitrogenous waste products in the gut reduces urea and creatinine concentrations in the blood of animal models of acute and chronic kidney injury.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/2
/ 13/31
/ 14/19
/ 14/34
/ 14/63
/ 38/5
/ 38/77
/ 38/79
/ 631/1647
/ 639/301
/ 9/10
/ Animals
/ Bacteria
/ Bacteria - isolation & purification
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Blood
/ Capsules - administration & dosage
/ Dialysis
/ Failure
/ Injuries
/ Kidneys
/ Mice
/ Mucosa
/ Nitrogen Compounds - isolation & purification
/ Nitrogen Compounds - metabolism
/ Renal Insufficiency - therapy
/ Swine
/ Urea
/ Wastes
