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PGR and PTX3 gene expression in cumulus cells from obese and normal weighting women after administration of long-acting recombinant follicle-stimulating hormone for controlled ovarian stimulation
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PGR and PTX3 gene expression in cumulus cells from obese and normal weighting women after administration of long-acting recombinant follicle-stimulating hormone for controlled ovarian stimulation
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PGR and PTX3 gene expression in cumulus cells from obese and normal weighting women after administration of long-acting recombinant follicle-stimulating hormone for controlled ovarian stimulation
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Journal Article
PGR and PTX3 gene expression in cumulus cells from obese and normal weighting women after administration of long-acting recombinant follicle-stimulating hormone for controlled ovarian stimulation
2019
Overview
Purpose
The present study aimed to determine clinical IVF parameters and gene expression in cumulus cells (CCs) in obese and normal weighting women after administration of 150 mcg of corifollitropin alfa for controlled ovarian hyperstimulation (COH).
Methods
150 mcg of corifollitropin alfa and gonadotropin releasing hormone antagonist were used for COH. Analysis of CC gene expression was performed using quantitative real-time PCR.
Results
We did not find significant differences in biochemical and clinical pregnancy rates between obese and normal weighting women. Obese women required twice as much of additional gonadotropins for ovarian stimulation and had a significantly lower proportion of good quality embryos on day 5 of IVF cycle. Expression of
PGR
and
PTX3
was significantly higher in CCs of obese women.
Conclusion
Obese women require significantly larger amounts of gonadotropins to achieve similar IVF success rates as normal weighting women. Differences in CC gene expression and smaller proportion of good quality embryos may imply that oocytes derived from obese women are of lower quality. Further studies are needed to evaluate whether obesity itself or the higher amount of gonadotropins used in obese women causes this effect.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ C-Reactive Protein - genetics
/ Embryos
/ Female
/ Fertilization in Vitro - methods
/ Follicle Stimulating Hormone - genetics
/ Gynecologic Endocrinology and Reproductive Medicine
/ Humans
/ Intracellular Signaling Peptides and Proteins - genetics
/ Medicine
/ Obesity
/ Obstetrics/Perinatology/Midwifery
/ Ovulation Induction - methods
/ Patients
/ Peptide Fragments - genetics
/ Quality
/ Serum Amyloid P-Component - genetics
/ Studies
/ Success
