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Extrafollicular proliferation of B‐blasts: Morphologic correlate to Spikevax‐induced lymphadenopathy
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Extrafollicular proliferation of B‐blasts: Morphologic correlate to Spikevax‐induced lymphadenopathy
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Journal Article
Extrafollicular proliferation of B‐blasts: Morphologic correlate to Spikevax‐induced lymphadenopathy
2022
Overview
A 30‐year‐old male developed a PET‐positive left‐sided cervical lymphadenopathy that was suspected representing metastasis of a known right‐sided papillary thyroid cancer. First‐dose‐application of Spikevax three weeks ago was neither reflected, nor reported to the pathologists. Diagnostic lymphadenectomy was performed showing extrafollicular proliferation of B‐blasts, likely attributable to the vaccine application. The extrafollicular proliferation of B‐blast pattern seems to be recurrent in mRNA COVID‐19 vaccine‐induced lymphadenopathies and is one of the morphological correlates to PET‐imaging reactivity in respective instances. Generally, this type lymphadenopathy is observable as primary reaction to antigens and may represent a diagnostic pitfall to large cell lymphomas with scattered tumor cells.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
