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Construction and Analysis of Immune Infiltration and Competing Endogenous RNA Network in Moyamoya Disease
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Construction and Analysis of Immune Infiltration and Competing Endogenous RNA Network in Moyamoya Disease
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Journal Article
Construction and Analysis of Immune Infiltration and Competing Endogenous RNA Network in Moyamoya Disease
2025
Overview
Moyamoya disease (MMD) is a cerebrovascular condition characterized by progressive stenosis of intracranial arteries, leading to stroke. While MMD was long considered a genetic disorder, emerging evidence suggests autoimmune mechanisms may contribute to its pathogenesis. The role of non-coding RNAs (ncRNAs) in the pathogenesis of MMD is under heated discussion, and a competitive endogenous RNA (ceRNA) network involving MMD-related ncRNAs has not been constructed. In this study, we integrated multiple bioinformatic analyses on transcriptomic data from the middle cerebral arteries of MMD patients and controls. Our analysis revealed a significant enrichment of innate immune system pathways, including antigen processing and macrophage activation, in MMD tissue. We constructed a robust ceRNA network centered on the long non-coding RNA MALAT1, identifying 15 core mRNA targets. A classifier built from these MALAT1-related genes accurately distinguished MMD patients from controls, with an area under the curve of 0.869 in independent validation. Furthermore, immune deconvolution analysis showed a marked increase in microvascular endothelial cells and a decrease in CD4+ memory T cells and regulatory T cells in MMD arteries. The expression of the MALAT1 network genes strongly correlated with these shifts in cellular composition, positively with endothelial cells and negatively with T cells. Our findings uncover a MALAT1-driven ceRNA network that links immune dysregulation to vascular changes in MMD, highlighting MALAT1 as a potential biomarker and therapeutic target.
Publisher
MDPI AG,MDPI
Subject
/ Analysis
/ Antigens
/ Computational Biology - methods
/ Datasets
/ Disease
/ Diseases
/ Female
/ Genes
/ Humans
/ Ischemia
/ Male
/ Middle Cerebral Artery - immunology
/ Middle Cerebral Artery - metabolism
/ Middle Cerebral Artery - pathology
/ Moyamoya Disease - immunology
/ Moyamoya Disease - pathology
/ RNA, Long Noncoding - genetics
/ T cells
