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Higher Content of 18:1 Trans Fatty Acids in Subcutaneous Fat of Persons with Coronarographically Documented Atherosclerosis of the Coronary Arteries
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Higher Content of 18:1 Trans Fatty Acids in Subcutaneous Fat of Persons with Coronarographically Documented Atherosclerosis of the Coronary Arteries
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Higher Content of 18:1 Trans Fatty Acids in Subcutaneous Fat of Persons with Coronarographically Documented Atherosclerosis of the Coronary Arteries
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Journal Article
Higher Content of 18:1 Trans Fatty Acids in Subcutaneous Fat of Persons with Coronarographically Documented Atherosclerosis of the Coronary Arteries
2003
Overview
Aim: To identify the total content of trans fatty acid (TFA) isomers and C18:1 trans isomers in subcutaneous fat samples from persons with atherosclerosis of the coronary arteries, as an indicator of dietary exposure. Methods: Using capillary gas chromatography, the authors determined total content of TFA isomers and C18:1 trans isomers in the subcutaneous fat of 34 patients with ischemic heart disease who had undergone aortocoronary bypass surgery and in 46 patients with no sign of coronary disease. Results: On average, the total TFAs in cardiac patients were 2.88 ± 1.19% of all fatty acids, in noncardiac patients 2.56 ± 0.89%. However, the difference is not statistically significant. The average concentration of C18:1 trans in cardiac patients (2.31 ± 1.09%) was statistically significantly higher (p = 0.05) than in the noncardiac group (1.95 ± 0.77%). Conclusions: The results obtained indicate a lower TFA load in comparison with previous studies in other countries. A higher concentration of 18:1 TFAs in the subcutaneous fat of patients with coronary disease might be an impulse to correct the dietary habits of this very high-risk population.
Publisher
S. Karger AG,Karger
Subject
/ analysis
/ Atherosclerosis (general aspects, experimental research)
/ Biological and medical sciences
/ Butter
/ Coronary Artery Disease - metabolism
/ Diet
/ Dietary Fats, Unsaturated - administration & dosage
/ etiology
/ fat body
/ Female
/ Heart
/ Humans
/ Ischemia
/ isomers
/ Male
/ Medicine
/ patients
/ surgery
