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Targeting B Cells and Plasma Cells in Autoimmune Diseases
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Journal Article
Targeting B Cells and Plasma Cells in Autoimmune Diseases
2018
Overview
Success with B cell depletion using rituximab has proven the concept that B lineage cells represent a valid target for the treatment of autoimmune diseases, and has promoted the development of other B cell targeting agents. Present data confirm that B cell depletion is beneficial in various autoimmune disorders and also show that it can worsen the disease course in some patients. These findings suggest that B lineage cells not only produce pathogenic autoantibodies, but also significantly contribute to the regulation of inflammation. In this review, we will discuss the multiple pro- and anti-inflammatory roles of B lineage cells play in autoimmune diseases, in the context of recent findings using B lineage targeting therapies.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Antigens
/ Arthritis, Rheumatoid - immunology
/ Arthritis, Rheumatoid - physiopathology
/ Autoimmune Diseases - immunology
/ Autoimmune Diseases - physiopathology
/ B cells
/ B-Lymphocytes - drug effects
/ Bortezomib - administration & dosage
/ Cells
/ Humans
/ Ligands
/ Mice
/ Plasma
/ Rituximab - administration & dosage
/ Spleen
