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Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study
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Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study
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Journal Article
Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study
2024
Overview
Background
Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy obesity by comparing clinical profile-matched metabolically healthy obesity and non-obesity groups.
Methods
We analyzed a health insurance dataset with annual health checkup data from Japan. The analyzed data included 168,699 individuals aged <65 years. Obesity was defined as ≥25 kg/m
2
body mass index. Metabolically healthy was defined as ≤1 metabolic risk factor (high blood pressure, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol, or high hemoglobin A1c). Incidence rates of stroke, myocardial infarction, and all-cause mortality identified from the insurance data were compared between metabolically healthy obesity and non-obesity groups (
n
= 8644 each) using a log-rank test.
Results
The stroke (obesity: 9.2 per 10,000 person-years; non-obesity: 10.5; log-rank test
p
= 0.595), myocardial infarction (obesity: 3.7; non-obesity: 3.1;
p
= 0.613), and all-cause mortality (obesity: 26.6; non-obesity: 23.2;
p
= 0.304) incidence rates did not differ significantly between the metabolically healthy obesity and non-obesity groups, even when the abdominal obesity was considered in the analysis. The lack of association was also observed in the comparison between the metabolically unhealthy obesity and non-obesity groups (
n
= 10,965 each). The population with metabolically healthy obesity reported negligibly worse metabolic profiles than the population with non-obesity at the 5.6-year follow-up.
Conclusion
Obesity, when accompanied by a healthy metabolic profile, did not increase the risk of cardiovascular outcomes and all-cause mortality.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Cardiovascular Diseases - epidemiology
/ Cardiovascular Diseases - mortality
/ Density
/ Female
/ Health Promotion and Disease Prevention
/ Humans
/ Male
/ Medicine
/ Obesity
/ Obesity, Metabolically Benign - complications
/ Obesity, Metabolically Benign - epidemiology
/ Obesity, Metabolically Benign - mortality
/ Stroke
