Journal Article

Protein photo-folding and quantum folding theory

LUO LiaoFu

2012

Overview

The rates of protein folding with photon absorption or emission and the cross section of photon -protein inelastic scattering are calculated from quantum folding theory by use of a field-theoretical method. All protein photo-folding processes are compared with common protein folding without the interaction of photons （non-radiative folding）. It is demonstrated that there exists a common factor （thermo-averaged overlap integral of the vibration wave function, TAOI） for protein folding and protein pho- to-folding. Based on this finding it is predicted that （i） the stimulated photo-folding rates and the photon-protein resonance Raman scattering sections show the same temperature dependence as protein folding; （ii） the spectral line of the electronic transition is broadened to a band that includes an abundant vibration spectrum without and with conformational transitions, and the width of each vibration spectral line is largely reduced. The particular form of the folding rate--temperature relation and the abundant spectral structure imply the existence of quantum tunneling between protein conformations in folding and pho- to-folding that demonstrates the quantum nature of the motion of the conformational-electronic system.

• Publisher: Science China Press,Springer Nature B.V
• Subject: Algorithms / Biomedical and Life Sciences / Life Sciences / Models, Chemical / Photons / Protein Folding / Proteins - chemistry / Quantum Theory / Research Paper / Spectrum Analysis, Raman / Temperature / Thermodynamics / 光子吸收 / 振动频谱 / 照片 / 电子系统 / 蛋白质折叠 / 蛋白质构象 / 量子隧道 / 非弹性散射截面