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The global prevalence of Huntington's disease: a systematic review and discussion
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The global prevalence of Huntington's disease: a systematic review and discussion
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Journal Article
The global prevalence of Huntington's disease: a systematic review and discussion
2016
Overview
The ascertained prevalence of Huntington's disease (HD) increased significantly following the provision of diagnostic testing. A systematic review was conducted to estimate the prevalence of HD in the post-diagnostic testing era. 22 studies with original data pertaining to the prevalence of HD (1993-2015) were included and analyzed. A global meta-analysis was not performed due to heterogeneity in study methods and geographical variation. The prevalence of HD is significantly lower in Asian populations compared with western Europe, North America and Australia. The global variation in HD prevalence is partly explained by the average CAG repeat lengths and frequency of different
gene haplotypes in the general population. Understanding the prevalence of HD has significant implications for healthcare resource planning.
Publisher
Future Medicine Ltd
