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Outcomes of large vestibular schwannomas following subtotal resection: early post-operative volume regression and facial nerve function
by
Trifiletti, Daniel M.
, Lundy, Larry B.
, Wharen, Robert E.
, Akinduro, Oluwaseun O.
, Lu, Victor M.
, Gupta, Vivek
, Quinones-Hinojosa, Alfredo
in
Adult
/ Aged
/ Aged, 80 and over
/ Brain cancer
/ Clinical Study
/ Facial nerve
/ Facial Nerve - physiopathology
/ Female
/ Follow-Up Studies
/ Humans
/ Male
/ Medical records
/ Medicine
/ Medicine & Public Health
/ Middle Aged
/ Neoplasm, Residual - pathology
/ Neoplasm, Residual - surgery
/ Neurology
/ Neuroma, Acoustic - pathology
/ Neuroma, Acoustic - surgery
/ Oncology
/ Patients
/ Postoperative Complications
/ Radiosurgery - methods
/ Retrospective Studies
/ Schwann cells
/ Surgery
/ Treatment Outcome
/ Tumor Burden
/ Tumors
/ Vestibular system
/ Young Adult
2019
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Outcomes of large vestibular schwannomas following subtotal resection: early post-operative volume regression and facial nerve function
by
Trifiletti, Daniel M.
, Lundy, Larry B.
, Wharen, Robert E.
, Akinduro, Oluwaseun O.
, Lu, Victor M.
, Gupta, Vivek
, Quinones-Hinojosa, Alfredo
in
Adult
/ Aged
/ Aged, 80 and over
/ Brain cancer
/ Clinical Study
/ Facial nerve
/ Facial Nerve - physiopathology
/ Female
/ Follow-Up Studies
/ Humans
/ Male
/ Medical records
/ Medicine
/ Medicine & Public Health
/ Middle Aged
/ Neoplasm, Residual - pathology
/ Neoplasm, Residual - surgery
/ Neurology
/ Neuroma, Acoustic - pathology
/ Neuroma, Acoustic - surgery
/ Oncology
/ Patients
/ Postoperative Complications
/ Radiosurgery - methods
/ Retrospective Studies
/ Schwann cells
/ Surgery
/ Treatment Outcome
/ Tumor Burden
/ Tumors
/ Vestibular system
/ Young Adult
2019
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Outcomes of large vestibular schwannomas following subtotal resection: early post-operative volume regression and facial nerve function
by
Trifiletti, Daniel M.
, Lundy, Larry B.
, Wharen, Robert E.
, Akinduro, Oluwaseun O.
, Lu, Victor M.
, Gupta, Vivek
, Quinones-Hinojosa, Alfredo
in
Adult
/ Aged
/ Aged, 80 and over
/ Brain cancer
/ Clinical Study
/ Facial nerve
/ Facial Nerve - physiopathology
/ Female
/ Follow-Up Studies
/ Humans
/ Male
/ Medical records
/ Medicine
/ Medicine & Public Health
/ Middle Aged
/ Neoplasm, Residual - pathology
/ Neoplasm, Residual - surgery
/ Neurology
/ Neuroma, Acoustic - pathology
/ Neuroma, Acoustic - surgery
/ Oncology
/ Patients
/ Postoperative Complications
/ Radiosurgery - methods
/ Retrospective Studies
/ Schwann cells
/ Surgery
/ Treatment Outcome
/ Tumor Burden
/ Tumors
/ Vestibular system
/ Young Adult
2019
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Outcomes of large vestibular schwannomas following subtotal resection: early post-operative volume regression and facial nerve function
Journal Article
Outcomes of large vestibular schwannomas following subtotal resection: early post-operative volume regression and facial nerve function
2019
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Overview
Introduction
Subtotal resection (STR) of vestibular schwannoma (VS) tumors remains controversial and little is known regarding post-operative volume changes.
Methods
Authors retrospective reviewed the medical records from January 1st 2002 to January 1st 2018, for all patients who had undergone primary STR of large VS at a single tertiary academic institution.
Results
Our series consists of 34 patients with a mean age of 53.9 (median 53; range 21–87) years that had STR of their VS tumor. The mean pre-operative tumor diameter and volume was 3.9 cm (median 3.0 cm; range 1.6–6.0 cm) and 11.7 cm
3
(median 9.6 cm
3
; range 2.8–44.3 cm
3
), respectively, with a mean extent of resection of 86% (median 90%; range 53–99%). The mean radiographic and clinical follow-up was 40 months (range 6–120 months) and 51 months (range 7–141 months), respectively. 85% of patients had optimal House–Brackmann (HB) scores (Grade 1 & 2) immediately post-operatively, and 91% at 1 year; 94% of patients had normal (HB 1) at last follow-up. There was significant regression of residual tumor volume at 1 year (p = 0.006) and 2 years (p = 0.02), but not at 3 years (p = 0.08), when compared to the prior year. There was significant regression of size over time, with a mean slope estimate of − 0.70 units per year (p < 0.001).
Conclusion
Excellent clinical facial nerve outcomes can be obtained with STR of large VS tumors. Maximal reduction in tumor size occurs at 2-year post-operatively. Thus, in patients undergoing surgery for large VS, STR and a “watch and wait” strategy is a reasonable treatment option that may optimize facial nerve outcomes.
Publisher
Springer US,Springer Nature B.V
Subject
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