Journal Article

Quantitative sodium MR imaging of native versus transplanted kidneys using a dual-tuned proton/sodium (1H/23Na) coil: initial experience

Bae, Kyongtae Ty, Furlan, Alessandro, Kim, Jung-Hwan, Moon, Chan Hong, Zhao, Tiejun, Shapiro, Ron

2014

Overview

Objectives To compare sodium ( 23 Na) characteristics between native and transplanted kidneys using dual-tuned proton ( 1 H)/sodium MRI. Methods Six healthy volunteers and six renal transplant patients (3 normal function, 3 acute allograft rejection) were included. Proton/sodium MRI was obtained at 3 T using a dual-tuned coil. Signal to noise ratio (SNR), sodium concentration ([ 23 Na]) and cortico-medullary sodium gradient (CMSG) were measured. Reproducibility of [ 23 Na] measurement was also tested. SNR, [ 23 Na] and CMSG of the native and transplanted kidneys were compared. Results Proton and sodium images of kidneys were successfully acquired. SNR and [ 23 Na] measurements of the native kidneys were reproducible at two different sessions. [ 23 Na] and CMSG of the transplanted kidneys was significantly lower than those of the native kidneys: 153.5 ± 11.9 vs. 192.9 ± 9.6 mM ( P  = 0.002) and 8.9 ± 1.5 vs. 10.5 ± 0.9 mM/mm ( P  = 0.041), respectively. [ 23 Na] and CMSG of the transplanted kidneys with normal function vs. acute rejection were not statistically different. Conclusions Sodium quantification of kidneys was reliably performed using proton/sodium MRI. [ 23 Na] and CMSG of the transplanted kidneys were lower than those of the native kidneys, but without a statistically significant difference between patients with or without renal allograft rejection. Key Points • Dual-tuned proton/sodium RF coil enables co-registered proton and sodium MRI . • Structural and sodium biochemical property can be acquired by dual-tuned proton/sodium MRI . • Sodium and sodium gradient of kidneys can be measured by dual-tuned MRI . • Sodium concentration was lower in transplanted kidneys than in native kidneys . • Sodium gradient of transplanted kidneys was lower than for native kidneys .

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adult / Aged / Biopsy / Diagnostic Radiology / Equipment Design / Female / Graft Rejection - metabolism / Graft Rejection - pathology / Humans / Imaging / Internal Medicine / Interventional Radiology / Kidney Cortex - metabolism / Kidney Cortex - pathology / Kidney Medulla - metabolism / Kidney Medulla - pathology / Kidney Transplantation / Kidney transplants / Magnetic Resonance / Magnetic Resonance Imaging - instrumentation / Magnetic Resonance Imaging - methods / Magnetic Resonance Imaging - standards / Male / Medicine / Medicine & Public Health / Middle Aged / Neuroradiology / Prospective Studies / Protons / Radio Waves / Radiology / Reproducibility of Results / Signal to noise ratio / Sodium / Sodium - metabolism / Ultrasound