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Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial
by
Shah, Kiran
, Boyd, Richard
, Paterson, Kade
, Bates, Dan
, Freitag, Julien
, Wickham, James
, Tenen, Abi
, Huguenin, Leesa
in
Adipose Tissue - cytology
/ Arthritis
/ Clinical trials
/ Female
/ Humans
/ Injections, Intra-Articular
/ Knee
/ Male
/ Mesenchymal Stem Cell Transplantation - methods
/ Mesenchymal Stem Cells - cytology
/ Middle Aged
/ Osteoarthritis, Knee - therapy
/ Systematic review
/ Transplantation, Autologous
/ Treatment Outcome
2019
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Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial
by
Shah, Kiran
, Boyd, Richard
, Paterson, Kade
, Bates, Dan
, Freitag, Julien
, Wickham, James
, Tenen, Abi
, Huguenin, Leesa
in
Adipose Tissue - cytology
/ Arthritis
/ Clinical trials
/ Female
/ Humans
/ Injections, Intra-Articular
/ Knee
/ Male
/ Mesenchymal Stem Cell Transplantation - methods
/ Mesenchymal Stem Cells - cytology
/ Middle Aged
/ Osteoarthritis, Knee - therapy
/ Systematic review
/ Transplantation, Autologous
/ Treatment Outcome
2019
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Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial
by
Shah, Kiran
, Boyd, Richard
, Paterson, Kade
, Bates, Dan
, Freitag, Julien
, Wickham, James
, Tenen, Abi
, Huguenin, Leesa
in
Adipose Tissue - cytology
/ Arthritis
/ Clinical trials
/ Female
/ Humans
/ Injections, Intra-Articular
/ Knee
/ Male
/ Mesenchymal Stem Cell Transplantation - methods
/ Mesenchymal Stem Cells - cytology
/ Middle Aged
/ Osteoarthritis, Knee - therapy
/ Systematic review
/ Transplantation, Autologous
/ Treatment Outcome
2019
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Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial
Journal Article
Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial
2019
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Overview
To evaluate the efficacy of autologous adipose-derived mesenchymal stem cell (ADMSC) therapy on pain, function and disease modification in knee osteoarthritis.
30 participants with symptomatic knee osteoarthritis were randomized into three groups. Two treatment groups received intra-articular ADMSC therapy consisting of either a single injection (100 × 10
ADMSCs) or two injections (100 × 10
ADMSCs at baseline and 6 months). The third group served as control and continued conservative management.
No serious adverse events were observed. Both treatment groups receiving ADMSCs showed clinically significant pain and functional improvement at completion of follow-up at 12 months. Radiological analysis using the Magnetic Resonance Imaging Osteoarthritis Knee Score indicated modification of disease progression.
Autologous ADMSC therapy appears to be a safe and effective therapy for knee osteoarthritis and may have the potential to prevent disease progression.
Trial registration number: ACTRN12614000814673
Publisher
Future Medicine Ltd
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