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Experimental evidence for the therapeutic potential of tempol in the treatment of acute liver injury
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Experimental evidence for the therapeutic potential of tempol in the treatment of acute liver injury
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Journal Article
Experimental evidence for the therapeutic potential of tempol in the treatment of acute liver injury
2016
Overview
Oxidative stress is one of the mechanisms involved in the acute carbon tetrachloride (CCl
4
)-induced hepatotoxicity. Since 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, known as tempol, has powerful antioxidant properties, we investigated its potential hepatoprotective effects and the underlying mechanisms that may add further benefits for its clinical usefulness using an acute model of CCl
4
-induced hepatotoxicity. One hour after CCl
4
induction of acute hepatotoxicity, mice were treated with a daily dose of 20 mg/kg/day tempol for 3 days. It was found that treatment of animals with tempol significantly negated the pathological changes in liver function parameters as well as histology induced by CCl
4
. In addition, tempol significantly ameliorated CCl
4
-induced lipid peroxidation and GSH depletion, and improved catalase activity. Furthermore, tempol alleviated the inflammation induced by CCl
4
as indicated by reducing the liver expression level of nuclear factor-kappa B (NF-κB) and tumor necrosis factor-α (TNF-α). Finally, tempol significantly reduced expression level of the B-cell lymphoma-2 protein (Bcl-2) and active caspase-3 which are known markers of apoptosis. In conclusion, the present study provides important evidences for the promising hepatoprotective effects of tempol that can be explained by amelioration of oxidative stress mainly through replenishment of GSH, restoration of antioxidant enzyme activities, and reduction of lipid peroxides alongside its anti-inflammatory properties.
Publisher
Springer US,Springer Nature B.V
Subject
/ Biomedical and Life Sciences
/ Carbon
/ Carbon Tetrachloride Poisoning - complications
/ Chemical and Drug Induced Liver Injury - drug therapy
/ Chemical and Drug Induced Liver Injury - etiology
/ Chemical and Drug Induced Liver Injury - metabolism
/ Cyclic N-Oxides - therapeutic use
/ Liver
/ Lymphoma
/ Male
/ Mice
/ Oncology
/ Toxicity
