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Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol
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Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol
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Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol
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Journal Article
Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol
2016
Overview
Objective
To evaluate correlation between cumulative dose of gadobutrol and signal intensity (SI) within dentate nucleus and globus pallidus on unenhanced T1-weighted images in patients with relapsing-remitting multiple sclerosis (RRMS).
Methods
Dentate nucleus-to-pons and globus pallidus-to-thalamus SI ratios, and renal and liver functions, were evaluated after multiple intravenous administrations of 0.1 mmol/kg gadobutrol at 27, 96–98, and 168 weeks. We compared SI ratios based on the number of administrations, total amount of gadobutrol administered, and time between injections.
Results
Globus pallidus-to-thalamus (
p
= 0.025) and dentate nucleus-to-pons (
p
< 0.001) SI ratios increased after multiple gadobutrol administrations, correlated with the number of administrations (ρ = 0.263,
p
= 0.046, respectively) and depended on the length of administration (
p
= 0.017,
p
= 0.037, respectively). Patients receiving gadobutrol at 27 weeks showed the greatest increase in both SI ratios (
p
= 0.006;
p
= 0.014, respectively, versus 96–98 weeks). GGT increased at the end of the study (
p
= 0.004).
Conclusion
In patients with RRMS, SI within the dentate nucleus and globus pallidus increased on unenhanced T1-weighted images after multiple gadobutrol injections. Administration of the same total amount of gadobutrol over a shorter period caused greater SI increase.
Key points
•
Gadolinium deposition may occur within the human brain after multiple gadolinium contrast administrations
•
Increasing T1W signal intensity occurs within the dentate nucleus and globus pallidus
•
Increasing signal intensity may be a consequence of multiple administrations of gadobutrol
•
Administration of gadobutrol over a shorter period causes greater signal intensity increase
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Brain
/ Cerebellar Nuclei - pathology
/ Contrast Media - administration & dosage
/ Dose-Response Relationship, Drug
/ Female
/ Humans
/ Imaging
/ Magnetic Resonance Imaging - methods
/ Magnetic Resonance Spectroscopy - methods
/ Male
/ Medicine
/ Multiple Sclerosis, Relapsing-Remitting - pathology
/ Organometallic Compounds - administration & dosage
/ Toxicity
