Journal Article

Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria

Isberg, Ralph R., Geisinger, Edward

2017

Overview

Diseases caused by antibiotic-resistant bacteria in hospitals are the outcome of complex relationships between several dynamic factors, including bacterial pathogenicity, the fitness costs of resistance in the human host, and selective forces resulting from interventions such as antibiotic therapy. The emergence and fate of mutations that drive antibiotic resistance are governed by these interactions. In this review, we will examine how different forms of antibiotic resistance modulate bacterial fitness and virulence potential, thus influencing the ability of pathogens to evolve in the context of nosocomial infections. We will focus on 3 important multidrug-resistant pathogens that are notoriously problematic in hospitals: Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus. An understanding of how antibiotic resistance mutations shape the pathobiology of multidrug-resistant infections has the potential to drive novel strategies that can control the development and spread of drug resistance.

• Publisher: Oxford University Press
• Subject: Acinetobacter baumannii - drug effects / Acinetobacter baumannii - genetics / Acinetobacter baumannii - pathogenicity / Acinetobacter Infections - drug therapy / Animals / Anti-Bacterial Agents - pharmacology / Bacterial Proteins - genetics / Bacterial Proteins - metabolism / beta-Lactam Resistance - genetics / beta-Lactamases - genetics / beta-Lactamases - metabolism / Cross Infection - drug therapy / Drug Resistance, Multiple, Bacterial - genetics / Gene Expression Regulation, Bacterial / Humans / Microbial Sensitivity Tests / Mutation / Porins - genetics / Porins - metabolism / Pseudomonas aeruginosa - drug effects / Pseudomonas aeruginosa - genetics / Pseudomonas aeruginosa - pathogenicity / Pseudomonas Infections - drug therapy / Staphylococcal Infections - drug therapy / Staphylococcus aureus - drug effects / Staphylococcus aureus - genetics / Staphylococcus aureus - pathogenicity / Supplement / Virulence Factors - genetics