Asset Details
Do you wish to reserve the book?
The usefulness of angiotensin-(1-7) and des-Arg9-bradykinin as novel biomarkers for metabolic syndrome
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The usefulness of angiotensin-(1-7) and des-Arg9-bradykinin as novel biomarkers for metabolic syndrome
Do you wish to request the book?
The usefulness of angiotensin-(1-7) and des-Arg9-bradykinin as novel biomarkers for metabolic syndrome
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The usefulness of angiotensin-(1-7) and des-Arg9-bradykinin as novel biomarkers for metabolic syndrome
2021
Overview
The renin–angiotensin system (RAS) and the kallikrein– kinin system (KKS) closely interact with each other [1, 2] (Fig. 1). In the RAS, angiotensinogen cleavage by renin generates angiotensin I, which is thereafter cleaved by angiotensin-converting enzyme (ACE) to form angiotensin II. Angiotensin II then binds to the angiotensin II type 1 (AT1) receptor, resulting in the induction of vasoconstriction, inflammation, apoptosis, hypertrophy, cell proliferation, fibrosis, and oxidative stress [3]. On the other hand, angiotensin-(1-7), which is generated by the cleavage of angiotensin II by ACE2, by the cleavage of angiotensin I by neprilysin (NEP), or by the cleavage of angiotensin-(1-9) by ACE/NEP, binds to the Mas receptor and induces vasodilatation, antiinflammation, antiremodeling, antihypertrophy, antiproliferation, antiapoptosis, and antioxidation effects [3, 4]. Recently, oral administration of angiotensin-(1-7) has been reported to prevent obesity and hepatic inflammation in rats fed a high-fat diet [5].
Publisher
Nature Publishing Group
Subject
