Journal Article

Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive–compulsive disorder

Mizobe, Taro, Tsuruta, Sae, Nakao, Tomohiro, Nemoto, Kiyotaka, Murayama, Keitaro, Hiwatashi, Akio, Tomiyama, Hirofumi, Kato, Kenta, Ohno, Aikana, Togao, Osamu, Hasuzawa, Suguru, Tomita, Mayumi

2022

Overview

Recent evidence suggests that presupplementary motor area (pre‐SMA) and inferior frontal gyrus (IFG) play an important role in response inhibition. However, no study has investigated the relationship between these brain networks at resting‐state and response inhibition in obsessive–compulsive disorder (OCD). We performed resting‐state functional magnetic resonance imaging scans and then measured the response inhibition of 41 medication‐free OCD patients and 49 healthy control (HC) participants by using the stop‐signal task outside the scanner. We explored the differences between OCD and HC groups in the functional connectivity of pre‐SMA and IFG associated with the ability of motor response inhibition. OCD patients showed a longer stop‐signal reaction time (SSRT). Compared to HC, OCD patients exhibit different associations between the ability of motor response inhibition and the functional connectivity between pre‐SMA and IFG, inferior parietal lobule, dorsal anterior cingulate cortex, insula, and anterior prefrontal cortex. Additional analysis to investigate the functional connectivity difference from the seed ROIs to the whole brain voxels revealed that, compared to HC, OCD exhibited greater functional connectivity between pre‐SMA and IFG. Also, this functional connectivity was positively correlated with the SSRT score. These results provide additional insight into the characteristics of the resting‐state functional connectivity of the regions belonging to the cortico‐striato‐thalamo‐cortical circuit and the cingulo‐opercular salience network, underlying the impaired motor response inhibition of OCD. In particular, we emphasize the importance of altered functional connectivity between pre‐SMA and IFG for the pathophysiology of motor response inhibition in OCD. Obsessive–compulsive disorder patients had significantly different associations between the abilities of motor response inhibition and the resting‐state functional connectivity from pre‐SMA to IPL, IFG, dACC and anterior‐insula. Additionally, compared to healthy control, OCD exhibited greater functional connectivity between pre‐SMA and IFG, and this functional connectivity was correlated with the the abilities of motor response inhibition.

• Publisher: John Wiley & Sons, Inc
• Subject: Adult / Brain / Brain mapping / Cerebral Cortex - diagnostic imaging / Cerebral Cortex - physiopathology / cingulo‐opercular salience network / Circuits / Cognitive ability / Connectome / Corpus Striatum - diagnostic imaging / Corpus Striatum - physiopathology / Cortex (cingulate) / cortico‐striato‐thalamo‐cortical circuit / Female / Frontal gyrus / fronto‐striatal circuit / Functional magnetic resonance imaging / Humans / inferior frontal gyrus / Inhibition / Inhibition, Psychological / Magnetic Resonance Imaging / Male / Middle Aged / Motor Activity - physiology / Motor Cortex - diagnostic imaging / Motor Cortex - physiopathology / Nerve Net - diagnostic imaging / Nerve Net - physiopathology / Neural networks / Neuroimaging / Obsessive compulsive disorder / Obsessive-Compulsive Disorder - diagnostic imaging / Obsessive-Compulsive Disorder - physiopathology / Patients / Prefrontal cortex / Presupplementary motor area / presupplementary motor cortex / Reaction time / Reaction time task / response inhibition / resting‐state functional MRI / stop‐signal task / Thalamus - diagnostic imaging / Thalamus - physiopathology / ventral attention cortico‐striato‐thalamo‐cortical circuit / Young Adult