Journal Article

Selective ophthalmic arterial injection using a balloon catheter for retinoblastoma: a seven-year clinical evaluation

Suzuki, Shigenobu, Oguro, Sota, Mohri, Makoto, Chen, Yi Ning, Yamane, Takashi

2024

Overview

Purpose To evaluate the effectiveness and safety of selective ophthalmic arterial injection (SOAI) for retinoblastoma utilizing a microballoon catheter system with an M chamber. Study design Retrospective analysis. Methods and patients This study was sanctioned by theNational Cancer Center Hospital’ Independent Ethics Committee. The surgeon was a general interventional radiologist. After confirming that the distal internal carotid artery was not delineated by balloon occlusion and the ophthalmic artery was visualized using digital subtraction angiography, melphalan was manually administered. Notably, in cases presenting bilateral retinoblastoma, both eyes received treatment in a singular, low-dose procedure. Between July 2015 and December 2021, 125 patients with retinoblastoma (68 boys and 57 girls) underwent SOAI at our facility. The average age at initial treatment was 19.3 months. The study covered 250 procedures, with patients undergoing an average of 3.7 procedures. Results The success rate of the procedure was 99.2%, with a mean procedure duration of 18.3 min. Two distinct technical failures were recorded: one attributed to an internal carotid artery having a wide lumen and the other due to the ophthalmic artery remaining undetected on angiography post-balloon occlusion of the internal carotid artery. Adverse events were minimal but included bronchospasm post-procedure and severe orbital inflammation in 0.8% and 0.4% of cases, respectively. Conclusion SOAI using the microballoon catheter with the M chamber is a feasible and safe procedure for the treatment of retinoblastoma. The success rate was 99.2%. This system can be recommended as intra-arterial chemotherapy for retinoblastoma.

• Publisher: Springer Japan,Springer Nature B.V
• Subject: Angiography / Angiography, Digital Subtraction / Antineoplastic Agents, Alkylating - administration & dosage / Balloon catheters / Balloon treatment / Bronchospasm / Carotid arteries / Carotid artery / Catheters / Cerebral blood flow / Chambers / Chemotherapy / Child / Child, Preschool / Clinical Investigation / Female / Follow-Up Studies / Health services / Humans / Infant / Injection / Injections, Intra-Arterial / Ischemia / Male / Medical equipment / Medical imaging / Medical instruments / Medicine / Medicine & Public Health / Melphalan / Melphalan - administration & dosage / Microballoons / Occlusion / Ophthalmic Artery - diagnostic imaging / Ophthalmology / Patients / Retinal Neoplasms - diagnosis / Retinal Neoplasms - drug therapy / Retinal Neoplasms - therapy / Retinoblastoma / Retinoblastoma - diagnosis / Retinoblastoma - drug therapy / Retinoblastoma - therapy / Retrospective Studies / Treatment Outcome / Ultrasonic imaging / Veins & arteries