Journal Article

Multivariate word properties in fluency tasks reveal markers of Alzheimer's dementia

Slachevsky, Andrea, Amoruso, Lucía, Fittipaldi, Sol, Estienne, Claudio, Reyes, Pablo, Migeot, Joaquín, Birba, Agustina, Hesse, Eugenia, Pérez, Gonzalo, Serrano, Cecilia, Matallana, Diana, Ferrante, Franco J., Campo, Cecilia Gonzalez, Tagliazucchi, Enzo, Ibáñez, Agustín, García, Adolfo M.

2024

Overview

INTRODUCTION Verbal fluency tasks are common in Alzheimer's disease (AD) assessments. Yet, standard valid response counts fail to reveal disease‐specific semantic memory patterns. Here, we leveraged automated word‐property analysis to capture neurocognitive markers of AD vis‐à‐vis behavioral variant frontotemporal dementia (bvFTD). METHODS Patients and healthy controls completed two fluency tasks. We counted valid responses and computed each word's frequency, granularity, neighborhood, length, familiarity, and imageability. These features were used for group‐level discrimination, patient‐level identification, and correlations with executive and neural (magnetic resonanance imaging [MRI], functional MRI [fMRI], electroencephalography [EEG]) patterns. RESULTS Valid responses revealed deficits in both disorders. Conversely, frequency, granularity, and neighborhood yielded robust group‐ and subject‐level discrimination only in AD, also predicting executive outcomes. Disease‐specific cortical thickness patterns were predicted by frequency in both disorders. Default‐mode and salience network hypoconnectivity, and EEG beta hypoconnectivity, were predicted by frequency and granularity only in AD. DISCUSSION Word‐property analysis of fluency can boost AD characterization and diagnosis. Highlights We report novel word‐property analyses of verbal fluency in AD and bvFTD. Standard valid response counts captured deficits and brain patterns in both groups. Specific word properties (e.g., frequency, granularity) were altered only in AD. Such properties predicted cognitive and neural (MRI, fMRI, EEG) patterns in AD. Word‐property analysis of fluency can boost AD characterization and diagnosis.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc
• Subject: Alzheimer Disease - diagnosis / Alzheimer's disease / Brain / Brain - diagnostic imaging / Caregivers / Dementia / Discrimination / Disease / Disorders / Electroencephalography / Familiarity / Fluency / Frontotemporal / Frontotemporal Dementia - diagnosis / Functional magnetic resonance imaging / Humans / Imageability / Machine learning / Magnetic Resonance Imaging / Medical diagnosis / Medical imaging / Memory / Memory Disorders / Neighborhoods / neurodegeneration / Neuroimaging / Neuropsychological Tests / Neuropsychology / Patients / Phonology / Property / Salience / Semantic memory / Semantics / Sociodemographics / word properties