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Interactive effects of subanesthetic ketamine and haloperidol in healthy humans
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Interactive effects of subanesthetic ketamine and haloperidol in healthy humans
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Journal Article
Interactive effects of subanesthetic ketamine and haloperidol in healthy humans
1999
Overview
Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist with prominent psychoactive effects in humans. This study evaluated whether the oral administration of haloperidol 5 mg would block the effects of an intravenous ketamine infusion (bolus of 0.26 mg/kg followed by 0.65 mg/kg per hour). Twenty healthy subjects completed 4 test days involving the oral administration of haloperidol or matched placebo 2 h prior to the intravenous infusion of ketamine or saline. Ketamine produced cognitive, behavioral, neuroendocrine, and physiologic effects in the healthy subjects that were similar to previous reports. Haloperidol pretreatment reduced impairments in executive cognitive functions produced by ketamine as measured by proverb interpretations and the Wisconsin Card Sorting Test. However, it failed to block the capacity of ketamine to produce psychosis, perceptual changes, negative symptoms, or euphoria in healthy subjects. These data outline an important, but functionally delineated modulation of ketamine effects by dopamine2 receptors and other sites of haloperidol action.
Publisher
Springer,Springer Nature B.V
Subject
/ Anesthetics, Dissociative - pharmacology
/ Antipsychotic Agents - pharmacology
/ Biological and medical sciences
/ Female
/ Glutamic acid receptors (ionotropic)
/ Humans
/ Ketamine
/ Male
/ N-Methyl-D-aspartic acid receptors
/ Pharmacology. Drug treatments
/ Psycholeptics: tranquillizer, neuroleptic
/ Psychology. Psychoanalysis. Psychiatry
