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Phage libraries for generation of clinically useful antibodies

by Cochet, O. , Hawkins, R.E. , Boxer, G. , Keep, P.A. , Green, A. , Begent, R.H.J. , Pedley, R.B. , Boden LIBiol, J.A. , Chester, K.A. , Robson, L. , Winter, G.

in Animals / Antibodies / Antibodies, Monoclonal - biosynthesis / Antibodies, Monoclonal - genetics / Antibodies, Monoclonal - immunology / Antibodies, Neoplasm - biosynthesis / Antibodies, Neoplasm - genetics / Antibodies, Neoplasm - immunology / Antibody Affinity / Antibody Specificity / Bacteriophages - genetics / Bacteriophages - immunology / Biological and medical sciences / Cancer / Carcinoembryonic antigen / Carcinoembryonic Antigen - immunology / Carcinogenesis, carcinogens and anticarcinogens / E coli / Gene Library / General aspects / Genes / Genetic engineering / Humans / Immunity (Disease) / Immunoglobulins / Medical research / Medical sciences / Mice / Phages / Proteins / Tumors

1994

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Phage libraries for generation of clinically useful antibodies

by Cochet, O. , Hawkins, R.E. , Boxer, G. , Keep, P.A. , Green, A. , Begent, R.H.J. , Pedley, R.B. , Boden LIBiol, J.A. , Chester, K.A. , Robson, L. , Winter, G.

1994

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Phage libraries for generation of clinically useful antibodies

by Cochet, O. , Hawkins, R.E. , Boxer, G. , Keep, P.A. , Green, A. , Begent, R.H.J. , Pedley, R.B. , Boden LIBiol, J.A. , Chester, K.A. , Robson, L. , Winter, G.

1994

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Journal Article

Phage libraries for generation of clinically useful antibodies

Cochet, O.,

Hawkins, R.E.,

Boxer, G.,

Keep, P.A.,

Green, A.,

Begent, R.H.J.,

Pedley, R.B.,

Boden LIBiol, J.A.,

Chester, K.A.,

Robson, L.,

Winter, G.

1994

Overview

Insertion of antibody genes into filamentous bacteriophage makes it possible to generate and screen libraries of 107 or more antibodies. Each phage expresses an antibody on its surface and contains the corresponding antibody gene. Genes that encode antibodies with desired characteristics are readily selected and their antibodies expressed as soluble proteins in Escherichia coli. We used this system to produce an antibody to carcinoembryonic antigen with higher affinity and better tumour specificity than antibodies currently in use.

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Publisher

Elsevier Ltd,Lancet,Elsevier Limited

Subject

Animals

/ Antibodies

/ Antibodies, Monoclonal - biosynthesis

/ Antibodies, Monoclonal - genetics

/ Antibodies, Monoclonal - immunology

/ Antibodies, Neoplasm - biosynthesis

/ Antibodies, Neoplasm - genetics