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Is availability of artesunate associated with the prognosis of imported malaria in Spain?
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Journal Article
Is availability of artesunate associated with the prognosis of imported malaria in Spain?
2020
Overview
Artesunate (AS) has demonstrated its superiority against quinine for treatment of severe malaria in terms of reduction of mortality in different randomized clinical trials performed in endemic countries and subsequent meta-analysis [2–4]. [...]availability of AS seems to be associated with a better outcome in patients with imported malaria attending Spanish hospitals. Descriptive analysis Bivariate analysis Adjusted analysis n/N (%) OR (95% CI) p- value OR (95% CI) p- value Mortality Sex Male 53/5117 (1.04%) 1.12 (0.69–1.83) 0.628 1.34 (0.79–2.26) 0.275 Female 24/2609 (0.92%) Age >65 years 15/279 (5.38%) 6.77 (3.80–12.06) <0.001* 6.78 (3.65–12.61) <0.001* ≤65 years 62/7452 (0.83%) Nationality Foreigner/migrant 4/118 (3.39%) 3.82 (1.37–10.67) 0.010* 4.30 (1.53–12.10) 0.006* Spanish 66/7261 (0.91%) Secondary Outcome (mortality or >7 days of hospitalization) Sex Male 839/4196 (20.00%) 0.81 (0.72–0.92) 0.001* 0.83 (0.73–0.94) 0.004* Female 514/2186 (23.51%) Age >65 years 122/234 (52.14%) 4.36 (3.34–5.67) <0.001* 4.39 (3.36–5.74) <0.001* ≤65 years 1231/6153 (20.01%) Nationality Foreigner/migrant 35/120 (29.17%) 1.59 (1.06–2.37) 0.022* 1.72 (1.15–2.56) 0.008* Spanish 1261/6134 (20.56%) Table 1 Factors associated with mortality and long hospitalization in malaria patients admitted to hospital in Spain (2007–2017).
Publisher
Elsevier Ltd,Elsevier Limited
Subject
