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Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia

by Hogden, Laurie A , Peralta-Carcelen, Myriam , Khan, Amir M , McDavid, Georgia E , Keszler, Martin , Lowe, Jean R , Crawford, Margaret M , Maitre, Nathalie L , Natarajan, Girija , Adams-Chapman, Ira , DeMauro, Sara B , Purdy, Isabell B , Higgins, Rosemary D , Wilson-Costello, Deanne E , Watterberg, Kristi L , Walsh, Michele C , McGowan, Elisabeth C , Yoder, Bradley A , Truog, William E , Harmon, Heidi M , Reynolds, Anne M , Mosquera, Ricardo A , Hintz, Susan R , Van Meurs, Krisa P , Schmidt, Barbara , Bell, Edward F , Hibbs, Anna Maria , Winter, Sarah , Kennedy, Kathleen A , Backstrom-Lacy, Conra , Heyne, Roy J , Goldberg, Ronald N , Ambalavanan, Namasivayam , Merhar, Stephanie , Cotten, C. Michael , Sokol, Gregory M , Wyckoff, Myra H , Moallem, Mohannad , D’Angio, Carl T , Chess, Patricia R , Malcolm, William F , Chawla, Sanjay , Laughon, Matthew M , Garg, Meena , Hines, Abbey C , Poindexter, Brenda B , Das, Abhik , Meyer, Lauritz R , Patel, Ravi M , Li, Lei , Kilbride, Howard W

in Age / Airway Extubation / Birth weight / Body weight / Bronchopulmonary Dysplasia - epidemiology / Bronchopulmonary Dysplasia - prevention & control / Clinical Medicine / Critical Care / Critical Care General / Double-Blind Method / Dysplasia / Extubation / Follow-Up Studies / Gestational age / Glucocorticoids - administration & dosage / Glucocorticoids - adverse effects / Glucocorticoids - therapeutic use / Growth and Development / Hospital-Based Clinical Medicine / Humans / Hydrocortisone / Hydrocortisone - administration & dosage / Hydrocortisone - adverse effects / Hydrocortisone - therapeutic use / Infant, Extremely Premature / Infant, Newborn / Infant, Premature / Infants / Lung diseases / Mechanical Ventilation / Neonatology / Neurodevelopmental disorders / Neurodevelopmental Disorders - epidemiology / Neurodevelopmental Disorders - prevention & control / Neurology / Neurosurgery / Neurosurgery General / Oxygen Inhalation Therapy / Pediatrics / Pediatrics General / Placebos / Premature babies / Premature birth / Pulmonary / Respiration, Artificial / Sepsis / Steroids / Survival / Ventilators

2022

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2022

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2022

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Journal Article

Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia

Hogden, Laurie A,

Peralta-Carcelen, Myriam,

Khan, Amir M,

McDavid, Georgia E,

Keszler, Martin,

Lowe, Jean R,

Crawford, Margaret M,

Maitre, Nathalie L,

Natarajan, Girija,

Adams-Chapman, Ira,

DeMauro, Sara B,

Purdy, Isabell B,

Higgins, Rosemary D,

Wilson-Costello, Deanne E,

Watterberg, Kristi L,

Walsh, Michele C,

McGowan, Elisabeth C,

Yoder, Bradley A,

Truog, William E,

Harmon, Heidi M,

Reynolds, Anne M,

Mosquera, Ricardo A,

Hintz, Susan R,

Van Meurs, Krisa P,

Schmidt, Barbara,

Bell, Edward F,

Hibbs, Anna Maria,

Winter, Sarah,

Kennedy, Kathleen A,

Backstrom-Lacy, Conra,

Heyne, Roy J,

Goldberg, Ronald N,

Ambalavanan, Namasivayam,

Merhar, Stephanie,

Cotten, C. Michael,

Sokol, Gregory M,

Wyckoff, Myra H,

Moallem, Mohannad,

D’Angio, Carl T,

Chess, Patricia R,

Malcolm, William F,

Chawla, Sanjay,

Laughon, Matthew M,

Garg, Meena,

Hines, Abbey C,

Poindexter, Brenda B,

Das, Abhik,

Meyer, Lauritz R,

Patel, Ravi M,

Li, Lei,

Kilbride, Howard W

2022

Overview

Glucocorticoids might prevent bronchopulmonary dysplasia in extremely preterm infants but have adverse neurodevelopmental effects. In this trial involving preterm infants, there was little difference in survival without bronchopulmonary dysplasia or in the occurrence of neurodevelopmental impairment with hydrocortisone as compared with placebo.

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Publisher

Massachusetts Medical Society

Subject

/ Bronchopulmonary Dysplasia - epidemiology

/ Bronchopulmonary Dysplasia - prevention & control

/ Clinical Medicine