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PDADMAC/Alginate-Coated Gold Nanorod For Eradication of Staphylococcus Aureus Biofilms
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Journal Article
PDADMAC/Alginate-Coated Gold Nanorod For Eradication of Staphylococcus Aureus Biofilms
2024
Overview
Over 75% of clinical microbiological infections are caused by bacterial biofilms that grow on wounds or implantable medical devices. This work describes the development of a new poly(diallyldimethylammonium chloride) (PDADMAC)/alginate-coated gold nanorod (GNR/Alg/PDADMAC) that effectively disintegrates the biofilms of
(
), a prominent pathogen responsible for hospital-acquired infections.
GNR was synthesised via seed-mediated growth method, and the resulting nanoparticles were coated first with Alg and then PDADMAC. FTIR, zeta potential, transmission electron microscopy, and UV-Vis spectrophotometry analysis were performed to characterise the nanoparticles. The efficacy and speed of the non-coated GNR and GNR/Alg/PDADMAC in disintegrating
-preformed biofilms, as well as their in vitro biocompatibility (L929 murine fibroblast) were then studied.
The synthesised GNR/Alg/PDADMAC (mean length: 55.71 ± 1.15 nm, mean width: 23.70 ± 1.13 nm, aspect ratio: 2.35) was biocompatible and potent in eradicating preformed biofilms of methicillin-resistant (MRSA) and methicillin-susceptible
(MSSA) when compared to triclosan, an antiseptic used for disinfecting
colonisation on abiotic surfaces in the hospital. The minimum biofilm eradication concentrations of GNR/Alg/PDADMAC (MBEC
for MRSA biofilm = 0.029 nM; MBEC
for MSSA biofilm = 0.032 nM) were significantly lower than those of triclosan (MBEC
for MRSA biofilm = 10,784 nM; MBEC
for MRSA biofilm 5967 nM). Moreover, GNR/Alg/PDADMAC was effective in eradicating 50% of MRSA and MSSA biofilms within 17 min when used at a low concentration (0.15 nM), similar to triclosan at a much higher concentration (50 µM). Disintegration of MRSA and MSSA biofilms was confirmed by field emission scanning electron microscopy and confocal laser scanning microscopy.
These findings support the potential application of GNR/Alg/PDADMAC as an alternative agent to conventional antiseptics and antibiotics for the eradication of medically important MRSA and MSSA biofilms.
Publisher
Dove Medical Press Limited,Taylor & Francis Ltd,Dove Medical Press
Subject
/ Animals
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ biofilm
/ Biofilms
/ E coli
/ Gold
/ Metal Nanoparticles - chemistry
/ Methicillin-Resistant Staphylococcus aureus - drug effects
/ Methicillin-Resistant Staphylococcus aureus - physiology
/ Mice
/ mrsa
/ mssa
/ Multidrug resistant organisms
/ pdadmac
/ Polyethylenes - pharmacology
/ Quaternary Ammonium Compounds - chemistry
/ Quaternary Ammonium Compounds - pharmacology
/ Sodium
/ Staphylococcal Infections - drug therapy
/ Staphylococcus aureus - drug effects
