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Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site
by
Cotman, Carl W.
, Varon, Silvio
, Nieto-Sampedro, M.
, Barbin, Gilles
, Skaper, Stephen D.
, Lewis, Ellen R.
, Manthorpe, Marston
, Longo, Frank M.
in
Absorbable gelatin sponges
/ Adrenergic Fibers - physiology
/ Animals
/ Brain
/ Brain - physiology
/ Brain damage
/ Brain Injuries - physiopathology
/ Cell Survival - drug effects
/ Cells, Cultured
/ Central nervous system
/ Cholinergic Fibers - physiology
/ Ganglia
/ Kinetics
/ Lesions
/ Nerve Growth Factors - metabolism
/ Nerve Growth Factors - pharmacology
/ Nerve Regeneration
/ Nerve tissue
/ Nerves
/ Neurons
/ Physical trauma
/ Rats
/ Rats, Inbred Strains
/ Sprouting
/ Wound Healing
1982
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Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site
by
Cotman, Carl W.
, Varon, Silvio
, Nieto-Sampedro, M.
, Barbin, Gilles
, Skaper, Stephen D.
, Lewis, Ellen R.
, Manthorpe, Marston
, Longo, Frank M.
in
Absorbable gelatin sponges
/ Adrenergic Fibers - physiology
/ Animals
/ Brain
/ Brain - physiology
/ Brain damage
/ Brain Injuries - physiopathology
/ Cell Survival - drug effects
/ Cells, Cultured
/ Central nervous system
/ Cholinergic Fibers - physiology
/ Ganglia
/ Kinetics
/ Lesions
/ Nerve Growth Factors - metabolism
/ Nerve Growth Factors - pharmacology
/ Nerve Regeneration
/ Nerve tissue
/ Nerves
/ Neurons
/ Physical trauma
/ Rats
/ Rats, Inbred Strains
/ Sprouting
/ Wound Healing
1982
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Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site
by
Cotman, Carl W.
, Varon, Silvio
, Nieto-Sampedro, M.
, Barbin, Gilles
, Skaper, Stephen D.
, Lewis, Ellen R.
, Manthorpe, Marston
, Longo, Frank M.
in
Absorbable gelatin sponges
/ Adrenergic Fibers - physiology
/ Animals
/ Brain
/ Brain - physiology
/ Brain damage
/ Brain Injuries - physiopathology
/ Cell Survival - drug effects
/ Cells, Cultured
/ Central nervous system
/ Cholinergic Fibers - physiology
/ Ganglia
/ Kinetics
/ Lesions
/ Nerve Growth Factors - metabolism
/ Nerve Growth Factors - pharmacology
/ Nerve Regeneration
/ Nerve tissue
/ Nerves
/ Neurons
/ Physical trauma
/ Rats
/ Rats, Inbred Strains
/ Sprouting
/ Wound Healing
1982
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Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site
Journal Article
Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site
1982
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Overview
A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.
Publisher
The American Association for the Advancement of Science,American Association for the Advancement of Science
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