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Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

by Rezai Jahromi, Behnam , Nikolaev, Sergey I , Herman, Alexander M , Mendes Pereira, Vitor , Andrade-Barazarte, Hugo , Jauhiainen, Suvi , Fish, Jason E , Suutarinen, Santeri , Antonarakis, Stylianos E , DiStefano, Peter V , Tymianski, Mike , Zadeh, Gelareh , Wythe, Joshua D , Bonilla, Ximena , Khyzha, Nadiya , Rauramaa, Tuomas , Tung, Takyee , Krings, Timo , Frösen, Juhana , Ylä-Herttuala, Seppo , Radovanovic, Ivan , Valiante, Taufik , Vetiska, Sandra , Boudreau, Emilie , Kiehl, Tim-Rasmus

in Adult / Angiogenesis / Arteries / Brain / Brain research / Cells, Cultured / Children / Deoxyribonucleic acid / DNA / DNA Mutational Analysis / DNA sequencing / Endothelial cells / Exome / Extracellular signal-regulated kinase / Gene Expression / Genetic testing / Hemorrhage / Human Umbilical Vein Endothelial Cells - metabolism / Humans / Intracranial Arteriovenous Malformations - etiology / Intracranial Arteriovenous Malformations - genetics / Intracranial Arteriovenous Malformations - pathology / K-Ras protein / MAP kinase / MAP Kinase Kinase Kinases - metabolism / MAP Kinase Signaling System / Mutation / Neurosciences / Neurosurgery / Notch protein / Pathology / Patients / Phosphorylation / Protein kinase / Proto-Oncogene Proteins p21(ras) - genetics / Proto-Oncogene Proteins p21(ras) - metabolism / Signal transduction / Stroke / Veins & arteries

2018

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Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

2018

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2018

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Journal Article

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

Rezai Jahromi, Behnam,

Nikolaev, Sergey I,

Herman, Alexander M,

Mendes Pereira, Vitor,

Andrade-Barazarte, Hugo,

Jauhiainen, Suvi,

Fish, Jason E,

Suutarinen, Santeri,

Antonarakis, Stylianos E,

DiStefano, Peter V,

Tymianski, Mike,

Zadeh, Gelareh,

Wythe, Joshua D,

Bonilla, Ximena,

Khyzha, Nadiya,

Rauramaa, Tuomas,

Tung, Takyee,

Krings, Timo,

Frösen, Juhana,

Ylä-Herttuala, Seppo,

Radovanovic, Ivan,

Valiante, Taufik,

Vetiska, Sandra,

Boudreau, Emilie,

Kiehl, Tim-Rasmus

2018

Overview

Tissue samples of arteriovenous malformations of the brain were obtained from 72 patients. The majority of the samples had an activating mutation in KRAS, a gene previously implicated in tumorigenesis.

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Publisher

Massachusetts Medical Society

Subject

/ Brain