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A FUT2 Gene Common Polymorphism Determines Resistance to Rotavirus A of the P8 Genotype
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A FUT2 Gene Common Polymorphism Determines Resistance to Rotavirus A of the P8 Genotype
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Journal Article
A FUT2 Gene Common Polymorphism Determines Resistance to Rotavirus A of the P8 Genotype
2014
Overview
Attachment to carbohydrates of the histo-blood group type of several human Rotavirus strains (RVA) has recently been described. Synthesis of these ligands requires a functional FUT2 enzyme, suggesting that FUT2 null homozygote (ie, nonsecretor) individuals may not be recognized by most human RVA strains. Whereas such individuals represent 20% of the control population, this retrospective study determined that none of 51 patients infected by P[8] rotavirus strains were nonsecretors. The lack of α1,2fucosylated carbohydrate motifs in the gut surface mucosa is thus associated with resistance to symptomatic infection and virus attachment to such motifs is essential to the infection process.
Publisher
Oxford University Press
Subject
/ Adult
/ Aged
/ Antigens
/ Biological and medical sciences
/ Child
/ Disease Resistance - genetics
/ Etiology
/ Fucosyltransferases - genetics
/ Fundamental and applied biological sciences. Psychology
/ Galactoside 2-alpha-L-fucosyltransferase
/ Genotype
/ Humans
/ Infant
/ Ligands
/ Reverse Transcriptase Polymerase Chain Reaction
/ Rotavirus - isolation & purification
/ Rotavirus Infections - genetics
/ Rotavirus Infections - virology
/ Virology
/ VIRUSES
