Journal Article

Cord-Blood Transplantation in Patients with Minimal Residual Disease

Sandmaier, Brenda M, Flowers, Mary E, Deeg, Joachim H, Sorror, Mohamed, Dahlberg, Ann, Delaney, Colleen, Witherspoon, Robert, Appelbaum, Frederick R, Wood, Brent, Salit, Rachel, Woolfrey, Ann, Mielcarek, Marco, Doney, Kristine, Gooley, Ted, Petersdorf, Effie, Milano, Filippo

2016

Overview

Patients with minimal residual disease who received a cord-blood transplant had a higher probability of survival than those receiving a transplant from mismatched unrelated donors and a lower risk of relapse than those receiving a transplant from matched or mismatched unrelated donors. The preferred donor for patients who are in need of an allogeneic hematopoietic-cell transplant remains an HLA-identical sibling. Such a donor is not available for the majority (approximately 70%) of patients, and alternative donor sources are necessary. 1 At the Fred Hutchinson Cancer Research Center, the first alternative choice for patients who do not have an HLA-identical sibling has been an unrelated donor who has been matched with the patient at the allele level for HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 (a so-called 10/10 match, or an HLA-matched unrelated donor). However, approximately 50% of white patients who do not have an . . .

• Publisher: Massachusetts Medical Society
• Subject: Adolescent / Adult / Aged / Blood & organ donations / Bone marrow / Child / Child, Preschool / Cord Blood Stem Cell Transplantation - adverse effects / Female / Flow Cytometry / Histocompatibility antigen HLA / Histocompatibility Testing / Humans / Infant / Leukemia / Leukemia, Myeloid, Acute - therapy / Male / Middle Aged / Minimal residual disease / Myelodysplastic syndrome / Myelodysplastic Syndromes - therapy / Neoplasm, Residual - mortality / Neoplasm, Residual - therapy / Patients / Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy / Recurrence / Retrospective Studies / Risk assessment / Survival Analysis / Transplantation / Transplantation, Homologous / Transplants & implants / Young Adult