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A Rising Crisis: Escalating Burden of Diabetes Mellitus and Hypertension‐Related Mortality Trends in the United States, 2000–2023
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A Rising Crisis: Escalating Burden of Diabetes Mellitus and Hypertension‐Related Mortality Trends in the United States, 2000–2023
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A Rising Crisis: Escalating Burden of Diabetes Mellitus and Hypertension‐Related Mortality Trends in the United States, 2000–2023
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Journal Article
A Rising Crisis: Escalating Burden of Diabetes Mellitus and Hypertension‐Related Mortality Trends in the United States, 2000–2023
2025
Overview
Introduction Diabetes mellitus and hypertension are major contributors to cardiovascular and renal disease mortality, yet their combined long‐term impact on mortality trends in the United States remains underexplored. This study evaluates national trends in DM and hypertension‐related mortality from 2000 to 2023, analyzing disparities across sex, age groups, race/ethnicity, urbanization, and geographic regions. Methods We analyzed mortality data from the CDC‐WONDER database, identifying deaths with DM and hypertension as listed causes among adults aged 25 and older. Age‐adjusted mortality rates (AAMRs) per 100,000 were calculated, and temporal trends were assessed using Joinpoint regression to determine annual percentage changes. Results A total of 2,742,668 DM and hypertension‐related deaths were recorded. The AAMR nearly doubled from 33.7 per 100,000 in 2000 to 66.2 per 100,000 in 2023. A sharp increase was observed from 2018 to 2021 (APC: 16.3 [95% CI: 11.8–19.6]), followed by a decline through 2023. Men had consistently higher mortality rates than females. Mortality rates were highest among older adults (65+ years), Non‐Hispanic Black individuals, and nonmetropolitan populations. The South had the highest mortality rates, with Mississippi and the District of Columbia reporting the greatest burden. Conclusions DM and hypertension‐related mortality has significantly increased over the past two decades, with notable demographic and geographic disparities. Public health interventions should prioritize high‐risk populations to mitigate mortality trends and improve health equity. Diabetes mellitus and hypertension‐related mortality nearly doubled in the United States from 2000 to 2023, with striking disparities across sex, age, race, and geography. Men, Non‐Hispanic Blacks, older adults, and residents of the South experienced the highest mortality rates, underscoring the urgent need for targeted strategies to reduce this growing burden.
