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A new generation of companion diagnostics: cobas BRAF, KRAS and EGFR mutation detection tests
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A new generation of companion diagnostics: cobas BRAF, KRAS and EGFR mutation detection tests
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Journal Article
A new generation of companion diagnostics: cobas BRAF, KRAS and EGFR mutation detection tests
2014
Overview
The cobas® (Roche) portfolio of companion diagnostics in oncology currently has three assays CE-marked for in vitro diagnostics. Two of these (EGFR and BRAF) are also US FDA-approved. These assays detect clinically relevant mutations that are correlated with response (BRAF, EGFR) or lack of response (KRAS) to targeted therapies such as selective mutant BRAF inhibitors in malignant melanoma, tyrosine kinases inhibitor in non-small cell lung cancer and anti-EGFR monoclonal antibodies in colorectal cancer, respectively. All these assays are run on a single platform using DNA extracted from a single 5 µm section of a formalin-fixed paraffin-embedded tissue block. The assays provide an 'end-to-end' solution from extraction of DNA to automated analysis and report on the cobas z 480. The cobas tests have shown robust and reproducible performance, with high sensitivity and specificity and low limit of detection, making them suitable as companion diagnostics for clinical use.
Publisher
Informa UK, Ltd,Taylor & Francis,Informa Healthcare
