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Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes
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Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes
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Journal Article
Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes
2013
Overview
Neurodevelopmental disorders such as intellectual disability, autism spectrum disorder and schizophrenia lack precise boundaries in their clinical definitions, epidemiology, genetics and protein–protein interactomes. This calls into question the appropriateness of current categorical disease concepts. Recently, there has been a rising tide to reformulate neurodevelopmental nosological entities from biology upward. To facilitate this developing trend, we propose that identification of unique proteomic signatures that can be strongly associated with patient’s risk alleles and proteome-interactome-guided exploration of patient genomes could define biological mechanisms necessary to reformulate disorder definitions.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Child Development Disorders, Pervasive - classification
/ Child Development Disorders, Pervasive - genetics
/ Child Development Disorders, Pervasive - metabolism
/ Developmental Disabilities - classification
/ Developmental Disabilities - genetics
/ Developmental Disabilities - metabolism
/ Humans
/ Medicine
/ Neurodevelopmental disorders
/ Review
