Journal Article

Coagulation dysfunction in patients with AECOPD and its relation to infection and hypercapnia

Mei, Xiaodong, Hu, Ruixue, Jiang, Xuqin, Liu, Mei

2021

Overview

Background Patients with chronic obstructive pulmonary disease (COPD) often have coagulation abnormalities. However, the factors that lead to coagulation dysfunction in acute exacerbation of COPD (AECOPD) remain insufficiently explored. This study aimed to investigate the factors affecting coagulation status in patients with COPD and their influence on thrombosis. Methods Data of COPD patients, including 135 cases in acute exacerbation stage and 44 cases in stable stage from Nov 2016 to Nov 2019 in our hospital, were collected. Healthy people (n = 135) were enrolled as the controls. The coagulation parameters, blood gas indexes and blood routine examination results were collected and analyzed. Results White blood count (WBC), neutrophil count, neutrophil percentage (N%), platelet (PLT), prothrombin time (PT), international normalized ratio (INR), fibrinogen (FIB), and activated partial thromboplastin time (APTT) increased, plasma thrombin time (TT) decreased in AECOPD group compared with the control group. In AECOPD group, PT, APTT, and FIB were positively correlated with neutrophils and C‐reaction protein levels. PT was positively correlated with PCO2 and negatively with pH. Thrombosis was observed in five acute exacerbation and three stable stage COPD patients. Conclusions Patients with AECOPD presented abnormal coagulation status, which was correlated to infection and hypercapnia and might be potentially the risk factor of thrombosis. Patients with AECOPD often have coagulation abnormalities. In this study, some factors such as infection and hypercapnia were found to be related to the coagulation abnormality and thrombosis in those patients

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc
• Subject: Acidosis / AECOPD / Aged / Biomarkers - blood / Blood / Blood Coagulation / Blood Gas Analysis / Blood platelets / C-Reactive Protein - metabolism / Chronic infection / Chronic obstructive pulmonary disease / coagulation / Disease / Disease Progression / Dyspnea / Female / Fibrinogen / Hospitals / Humans / Hypercapnia / Hypercapnia - blood / Hypercapnia - complications / infection / Infections - blood / Infections - complications / inflammation / Inflammation - blood / Laboratories / Leukocytes (neutrophilic) / Lung diseases / Male / Middle Aged / Neutrophils / Obstructive lung disease / Prothrombin / Pulmonary Disease, Chronic Obstructive - blood / Pulmonary Disease, Chronic Obstructive - complications / Risk factors / Spirometry / Statistical analysis / Thrombin / Thromboplastin / Thrombosis