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Ganglioside GM1 Mimicry in Campylobacter Strains from Sporadic Infections in the United States
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Ganglioside GM1 Mimicry in Campylobacter Strains from Sporadic Infections in the United States
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Journal Article
Ganglioside GM1 Mimicry in Campylobacter Strains from Sporadic Infections in the United States
1999
Overview
To determine whether GM1-like epitopes in Campylobacter species are specific to O serotypes associated with Guillain-Barré syndrome (GBS) or whether they are frequent among random Campylobacter isolates causing enteritis, 275 random enteritis-associated isolates of Campylobacter jejuni were analyzed. The isolates were collected in the United States using a cholera toxin-binding assay. Overall, 26.2% of the isolates were positive for the GM1-like epitope. Of the 36 different O serotypes in the sample, 21 (58.3%) contained no strains positive for GM1, whereas in 6 serotypes (16.7%), >50% of isolates were positive for GM1. GBSassociated serotypes were more likely to contain strains positive for GM1 than were non-GBS-associated serotypes (37.8% vs. 15.1%, P = .0116). The results suggest that humans are frequently exposed to strains exhibiting GM1-like mimicry and, while certain serotypes may be more likely to possess GM1-like epitopes, the presence of GM1-like epitopes on Campylobacter strains does not itself trigger GBS.
Publisher
University of Chicago Press,Oxford University Press
Subject
/ Biological and medical sciences
/ Campylobacter Infections - complications
/ Campylobacter Infections - microbiology
/ Campylobacter jejuni - classification
/ Campylobacter jejuni - immunology
/ Campylobacter jejuni - isolation & purification
/ Epitopes
/ Fundamental and applied biological sciences. Psychology
/ G(M1) Ganglioside - immunology
/ Humans
/ Lipopolysaccharides - immunology
/ Lipopolysaccharides - metabolism
