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Two-component systems required for virulence in Pseudomonas aeruginosa
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Two-component systems required for virulence in Pseudomonas aeruginosa
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Journal Article
Two-component systems required for virulence in Pseudomonas aeruginosa
2017
Overview
Abstract
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad range of hosts, in addition to thriving in a broad range of environmental conditions outside of hosts. With this versatility comes the need to tightly regulate its genome to optimise its gene expression and behaviour to the prevailing conditions. Two-component systems (TCSs) comprising sensor kinases and response regulators play a major role in this regulation. This minireview discusses the growing number of TCSs that have been implicated in the virulence of P. aeruginosa, with a special focus on the emerging theme of multikinase networks, which are networks comprising multiple sensor kinases working together, sensing and integrating multiple signals to decide upon the best response. The networks covered in depth regulate processes such as the switch between acute and chronic virulence (GacS network), the Cup fimbriae (Roc network and Rcs/Pvr network), the aminoarabinose modification of lipopolysaccharide (a network involving the PhoQP and PmrBA TCSs), twitching motility and virulence (a network formed from the Chp chemosensory pathway and the FimS/AlgR TCS), and biofilm formation (Wsp chemosensory pathway). In addition, we highlight the important interfaces between these systems and secondary messenger signals such as cAMP and c-di-GMP.
Two-component systems controlling the virulence of the opportunistic pathogen, Pseudomonas aeruginosa.
Publisher
Oxford University Press
Subject
Arabinose - analogs & derivatives
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biofilms
/ Cyclic GMP - analogs & derivatives
/ Fimbriae, Bacterial - genetics
/ Fimbriae, Bacterial - metabolism
/ Gene Expression Regulation, Bacterial
/ Genomes
/ Kinases
/ Lipopolysaccharides - metabolism
/ Pili
/ Pseudomonas aeruginosa - genetics
/ Pseudomonas aeruginosa - pathogenicity
