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Horse versus Rabbit Antithymocyte Globulin in Aplastic Anemia
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Horse versus Rabbit Antithymocyte Globulin in Aplastic Anemia
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Journal Article
Horse versus Rabbit Antithymocyte Globulin in Aplastic Anemia
2011
Overview
To the Editor:
In their randomized trial comparing rabbit antithymocyte globulin (ATG) with horse ATG, Scheinberg et al. (Aug. 4 issue)
1
report the superiority of horse ATG in terms of response and survival. We previously conducted a phase 2 study of rabbit ATG plus cyclosporine as first-line therapy in patients with severe aplastic anemia.
2
The perception of our transplantation team was that rabbit ATG led to a decreased risk of infusion reactions, an impression that was largely confirmed in our study. However, Scheinberg et al. report very little infusion-related toxicity with horse ATG, which has not been our experience. Several . . .
Publisher
Massachusetts Medical Society
