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Comparative Analyses of Cyanoacrylates for Barrier Protection and Incontinence‐Related Wash‐Off Resistance
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Comparative Analyses of Cyanoacrylates for Barrier Protection and Incontinence‐Related Wash‐Off Resistance
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Journal Article
Comparative Analyses of Cyanoacrylates for Barrier Protection and Incontinence‐Related Wash‐Off Resistance
2026
Overview
A comprehensive skincare regimen involves cleansing, moisturising, and using skin barrier protectants. Cyanoacrylate‐based protectants safeguard vulnerable skin from damage caused by moisture, friction, and shear. This research involved two ex vivo and two clinical studies comparing the wear duration and wash‐off resistance of a 100% cyanoacrylate and a solvent‐cyanoacrylate mixture. Effectiveness was assessed using an ex vivo porcine skin model simulating urinary incontinence, evaluated with Lucifer yellow dye penetration and Corneometry, and a clinical model using Corneometry. Two single‐blind clinical studies measured skin surface electrical capacitance in healthy volunteers. Study 1 (n = 42) evaluated the wear duration over 8 days, while Study 2 (n = 52) examined wash‐off resistance after nine washes with various cleansers. Ex vivo results showed that both products were effective under repeated moisture and abrasion conditions, with the 100% cyanoacrylate outperforming the solvent‐cyanoacrylate mixture. In clinical studies, both products maintained barrier protection throughout Study 1 (p < 0.007) and none of the cleansers significantly degraded either product in Study 2. In conclusion, the 100% cyanoacrylate provided superior protection compared to the solvent‐cyanoacrylate mixture. Both products demonstrated comparable wear duration and wash‐off resistance in clinical studies, but the 100% cyanoacrylate was more effective in ex vivo testing under harsh conditions.
