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Ingenol Mebutate Gel for Actinic Keratosis
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Ingenol Mebutate Gel for Actinic Keratosis
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Journal Article
Ingenol Mebutate Gel for Actinic Keratosis
2012
Overview
Actinic keratosis is a common precursor to squamous-cell carcinoma. Several topical treatments are effective but require weeks of application. In four randomized trials, topical treatment with ingenol mebutate for 2 to 3 days was effective in clearing actinic keratoses.
Actinic keratoses are premalignant lesions that are common in light-skinned populations worldwide.
1
In the United States, the most common form of lesion-directed therapy for actinic keratoses is cryosurgery, although other locally ablative therapies are used.
2
In addition to potential scarring, recurrence rates are high with some of these treatment approaches.
3
Other treatments for actinic keratosis are applied to an entire field of sun-damaged skin, and many studies have shown the emergence of clinically visible actinic keratoses after application. These treatments include imiquimod, fluorouracil, diclofenac, and photodynamic therapy.
1
Drawbacks to the self-applied topical field therapies currently available include a long duration . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Dermatologic Agents - adverse effects
/ Dermatologic Agents - therapeutic use
/ Diterpenes - adverse effects
/ Diterpenes - therapeutic use
/ Face
/ Facial Dermatoses - drug therapy
/ Facial Dermatoses - pathology
/ Female
/ Humans
/ Injuries of the skin. Diseases of the skin due to physical agents
/ Keratosis, Actinic - drug therapy
/ Keratosis, Actinic - pathology
/ Kinases
/ Male
/ Nonsteroidal anti-inflammatory drugs
/ Patients
/ Scalp
/ Scalp Dermatoses - drug therapy
/ Scalp Dermatoses - pathology
/ Skin
