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Oxandrolone Treatment Results in an Increased Risk of Gonadarche in Prepubertal Boys With Klinefelter Syndrome
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Oxandrolone Treatment Results in an Increased Risk of Gonadarche in Prepubertal Boys With Klinefelter Syndrome
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Journal Article
Oxandrolone Treatment Results in an Increased Risk of Gonadarche in Prepubertal Boys With Klinefelter Syndrome
2018
Overview
Klinefelter syndrome (KS) is a common genetic condition in which males have an extra X chromosome. KS is associated with testosterone deficiency, neurodevelopmental delays, and cardiometabolic disorders. There has been recent interest in prepubertal androgen treatment; however, the effects on puberty and gonadal function are unknown.
To compare onset of puberty and testicular function in prepubertal boys treated with 2 years of oxandrolone (Ox) vs placebo (Pl).
Double-blind, randomized, controlled trial.
Single tertiary care referral center.
Eighty prepubertal boys with KS; mean age: 8.0 ± 2.2 years (range: 4 to 12).
Ox 0.05 mg/kg vs identical-appearing Pl capsule given for 2 years.
Onset of gonadarche (testicular volume ≥4 mL) and onset of pubarche (Tanner 2 pubic hair); change in testicular hormone concentrations.
Ox-treated group had 20.5 times higher odds of reaching gonadarche (OR 95% CI: 6.5, 77.8) and 28.1 times higher odds of reaching pubarche (OR 95% CI: 8.8, 110.4) during the 2-year study period after adjusting for baseline age. Gonadarche and pubarche both occurred at a younger age in the Ox group (gonadarche: 9.8 ± 1.5 vs 12.1 ± 1.0 years, P < 0.001; pubarche: 10.2 ± 1.1 vs 11.6 ± 1.3 years, P = 0.02). Serum concentrations of testicular hormones and gonadotropins were not different between groups.
Two years of Ox treatment in prepubertal boys with KS results in an increased risk of early gonadarche, on average 2 years earlier than in Pl-treated boys. Ox did not affect serum concentrations of testicular hormones.
Publisher
Copyright Oxford University Press,Oxford University Press,Endocrine Society
Subject
/ Androgens - administration & dosage
/ Child
/ Hormones
/ Humans
/ Klinefelter Syndrome - blood
/ Klinefelter Syndrome - drug therapy
/ Klinefelter Syndrome - physiopathology
/ Male
/ Neurodevelopmental disorders
/ Oxandrolone - administration & dosage
/ Puberty
/ Testes
