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Clopidogrel with or without Omeprazole in Coronary Artery Disease
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Clopidogrel with or without Omeprazole in Coronary Artery Disease
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Journal Article
Clopidogrel with or without Omeprazole in Coronary Artery Disease
2010
Overview
In patients receiving dual antiplatelet therapy, omeprazole reduced the risk of upper-GI toxic effects but did not increase the risk of cardiovascular events; statistical power to assess cardiovascular events was low, however, so the findings are not definitive.
On the basis of data from several studies, clopidogrel has become the second most commonly used prescription drug worldwide.
1
–
9
Gastrointestinal hemorrhage is the most common serious bleeding complication from the use of long-term antiplatelet therapy.
10
,
11
Data from randomized studies support the concept that therapies reducing acidity decrease gastrointestinal complications of antiplatelet therapy involving aspirin, though the data are largely based on endoscopic end points; observational data also support this effect.
12
–
16
Randomized, controlled trials have shown that proton-pump inhibitors (PPIs) reduce the rate of recurrent gastrointestinal bleeding in high-risk patients receiving aspirin.
17
Observational studies, however, have suggested that . . .
Publisher
Massachusetts Medical Society
Subject
/ Aspirin
/ Biological and medical sciences
/ Cardiovascular Diseases - epidemiology
/ Coronary Artery Disease - drug therapy
/ Female
/ Gastrointestinal Hemorrhage - chemically induced
/ Gastrointestinal Hemorrhage - prevention & control
/ Heart
/ Humans
/ Male
/ Omeprazole - adverse effects
/ Omeprazole - therapeutic use
/ Platelet Aggregation Inhibitors - adverse effects
/ Platelet Aggregation Inhibitors - therapeutic use
/ Proton Pump Inhibitors - adverse effects
/ Proton Pump Inhibitors - therapeutic use
/ Studies
/ Ticlopidine - adverse effects
