Journal Article

Intermittent Fasting on Neurologic Diseases: Potential Role of Gut Microbiota

Guo, Mingke, Zhao, Yilin, Luo, Xiaoxiao, Luo, Ailin, Li, Shiyong, Wang, Xuan, Li, Yujuan

2023

Overview

As the global population ages, the prevalence of neurodegenerative diseases is surging. These disorders have a multifaceted pathogenesis, entwined with genetic and environmental factors. Emerging research underscores the profound influence of diet on the development and progression of health conditions. Intermittent fasting (IF), a dietary pattern that is increasingly embraced and recommended, has demonstrated potential in improving neurophysiological functions and mitigating pathological injuries with few adverse effects. Although the precise mechanisms of IF’s beneficial impact are not yet completely understood, gut microbiota and their metabolites are believed to be pivotal in mediating these effects. This review endeavors to thoroughly examine current studies on the shifts in gut microbiota and metabolite profiles prompted by IF, and their possible consequences for neural health. It also highlights the significance of dietary strategies as a clinical consideration for those with neurological conditions.

• Publisher: MDPI AG
• Subject: Amino acids / Bacteria / Brain research / Diet / Dietary fiber / Disease / Eating behavior / Eating disorders / Fasting / Food / Gastrointestinal Microbiome - physiology / Gut microbiota / Humans / Hypothyroidism / Intermittent Fasting / intestinal microorganisms / Lifestyles / Mental health / Metabolism / Metabolites / Microbiota / Microbiota (Symbiotic organisms) / Nervous system / Nervous system diseases / Neurodegenerative Diseases / Neurophysiology / Nutrition research / pathogenesis / Physiology / Thyroid gland / Type 2 diabetes / Weight control